阿尔茨海默病生物学标志物研究进展  

An Overview of Biomarkers in Alzheimer's Disease

作　　者：曲艳[1] 刘萍[1] 李晓红[1] 

机构地区：[1]大连市友谊医院神经内科,辽宁大连116001

出　　处：《医学与哲学（B）》2013年第10期55-57,60,共4页Medicine & Philosophy(B)

摘　　要：阿尔茨海默病(AD)是常见的中枢神经系统变性疾病,是痴呆最常见的病因,发病率高。病理特征为老年斑及神经元纤维缠结。AD的确诊有赖病理学,临床诊断极其耗时。由于尚无准确的早期诊断方法,常使AD患者错过早期治疗的时机,这成为制约有效防控AD的瓶颈问题。因此寻找高敏感性、特异性、无创性的生物学标志物对AD的早期诊断至关重要。本文仅将目前较为广泛研究的生物学标志物及其研究现状作一概述。分别对脑脊液、血液、尿液及唾液中的AD标志物作逐一介绍。Alzheimer＇s disease fAD） is a progressive neurodegenerative disorder and the most common form of dementia. The disease is confirmed by the presence of neuritic plaques and neurofibrillary tangles. The clinical diagnosis of AD depends on pathology and it is very time-consuming. The lack of early diagnosis of AD becomes critical bottleneck that hinders the effective treatment. As a result, looking for sensitive and specific, non-invasive biomarkers of AD is very important for the early diagnosis. In this review, we will discuss the various candidate markers in four spheres and their current status in AD diagnosis. We will respectively introduce cerebrospinal fluid, blood, urine and saliva biomarkers of AD, respectively.

关 键 词：阿尔茨海默病 生物学标志物 早期诊断 

分 类 号：R742[医药卫生—神经病学与精神病学]