Lineage Specifers:New Players in the Induction of Pluripotency  

作　　者：Jian Shu Hongkui Deng 

机构地区：[1]The MOE Key Laboratory of Cell Proliferation and Differentiation,College of Life Sciences,Peking University [2]Peking-Tsinghua Center for Life Sciences,Peking University [3]Laboratory of Chemical Genomics,School of Chemical Biology and Biotechnology,Peking University Shenzhen Graduate School

出　　处：《Genomics, Proteomics & Bioinformatics》2013年第5期259-263,共5页基因组蛋白质组与生物信息学报（英文版）

基　　金：supported by the National Basic Research Program of China(973 Program,Grant No.2012CB966401);the Key New Drug Creation and Manufacturing Program(Grant No.2011ZX09102-010-03);the National Science and Technology Major Project(Grant No.2013ZX10001003);the Ministry of Science and Technology(Grant No.2011DFA30730 and 2013DFG30680)and 111 Project

摘　　要：Pluripotency-associated factors and their rivals, lineage specifiers, have long been consid- ered the determining factors for the identity of pluripotent and differentiated cells, respectively. Therefore, factors that are employed for cellular reprogramming in order to induce pluripotency have been identified mainly from embryonic stem cell （ESC）-enriched and pluripotency-associated factors. Recently, lineage specifiers have been identified to play important roles in orchestrating the process of restoring pluripotency. In this review, we summarize the latest discoveries regarding cell fate conversion using pluripotency-associated factors and lineage specifiers. We highlight the value of the ＂seesaw＂ model in defining cellular identity, opening up a novel scenario to consider pluri- potency and lineage specification.Pluripotency-associated factors and their rivals, lineage specifiers, have long been consid- ered the determining factors for the identity of pluripotent and differentiated cells, respectively. Therefore, factors that are employed for cellular reprogramming in order to induce pluripotency have been identified mainly from embryonic stem cell （ESC）-enriched and pluripotency-associated factors. Recently, lineage specifiers have been identified to play important roles in orchestrating the process of restoring pluripotency. In this review, we summarize the latest discoveries regarding cell fate conversion using pluripotency-associated factors and lineage specifiers. We highlight the value of the ＂seesaw＂ model in defining cellular identity, opening up a novel scenario to consider pluri- potency and lineage specification.

关 键 词：Reprogramming iPSCs PLURIPOTENCY Lineage specifier Seesaw model Cell fate conversion 

分 类 号：R329[医药卫生—人体解剖和组织胚胎学]