PLURIPOTENCY

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The Role of Mir-34a and Mir-145 as Potential Biomarkers of Meningioma Recurrence
《Advances in Bioscience and Biotechnology》2025年第2期13-29,共17页Liliane Cristina da Silva Mucio Luiz de Assis Cirino Paulo Cezar Novais Álvaro Fabricio Lopes Rios Marcus Vinícius Batista Celani Janaína Regina Lellis Letícia Passi Turra Maria de Fátima Galli Sorita Tazima Fernanda Maris Peria Carlos Gilberto Carlotti Junior Daniela Pretti da Cunha Tirapelli 
The expression of miRNAs is associated with a variety of diseases, including neoplasms. In recent years, a large number of abnormally expressed miRNAs have been shown to be effective in understanding the oncogenesis, ...
关键词：MENINGIOMAS Tumor Recurrence microRNA Cell Pluripotency 
Reevaluation by the CRISPR/Cas9 knockout approach revealed that multiple pluripotency-associated lncRNAs are dispensable for pluripotency maintenance while Snora73a/b is essential for pluripotency exit
《Science China(Life Sciences)》2024年第10期2198-2212,共15页Zhen Li Xuefei Li Jingxia Lin Yangming Wang Huiqing Cao Jiajian Zhou 
supported by the National Natural Science Foundation of China(31900447,32070792 and 91940302);the Startup Foundation of Dermatology Hospital,Southern Medical University(2019RC06)。
Many long noncoding RNAs(lncRNAs)have been identified through siRNA-based screening as essential regulators of embryonic stem cell(ESC)pluripotency.However,the biological and molecular functions of most lncRNAs remain...
关键词：long noncoding RNAs embryonic stem cells CRISPR/Cas9 SNORNAS stem cell differentiation 
GPR160 regulates the self-renewal and pluripotency of mouse embryonic stem cells via JAK1/STAT3 signaling pathway
《Journal of Genetics and Genomics》2024年第10期1055-1065,共11页Shasha Fan Chuanliang Guo Guanheng Yang Lei Hong Hongyu Li Ji Ma Yiye Zhou Shuyue Fan Yan Xue Fanyi Zeng 
This work was funded by grants from the National Key Research and Development Program of China(2019YFA0801402);the National Natural Science Foundation of China(82271890);the Shanghai Key Clinical Specialty Project(shslczdzk05705);the Shanghai Top Priority Key Discipline Project(2017zz02019);Innovative Research Team of High-Level Local Universities in Shanghai(SHSMU-ZDCX20212200);the Macao Science and Technology Development fund(FDCT)(0092/2022/A2 and 003/2022/ALC).
G-protein-coupled receptors(GPCRs)are the largest family of transmembrane receptors and regulate various physiological and pathological processes.Despite extensive studies,the roles of GPCRs in mouse embryonic stem ce...
关键词：Embryonic stem cell GPCR GPR160 JAK1/STAT3 signaling pathway 
A single-cell transcriptome atlas reveals the trajectory of early cell fate transition during callus induction in Arabidopsis
《Plant Communications》2024年第8期18-31,共14页Ruilian Yin Ruiying Chen Keke Xia Xun Xu 
supported by the National Key R&D Program of China(2022YFC3400300);the Guangdong Provincial Key Laboratory of Genome Read and Write(no.2017B030301011);the Shenzhen Key Laboratory of Single-Cell Omics(no.ZDSYS20190902093613831);the Guangdong Genomics Data Center(2021B1212100001);the theme project of Shenzhen Institute of Synthetic Biology(no.ZTXM20190004).
The acquisition of pluripotent callus from somatic cells plays an important role in plant development studies and crop genetic improvement.This developmental process incorporates a series of cell fate transitions and ...
关键词：callus induction single-cell RNA-seq cell fate transition developmental trajectory transcriptional regulation PLURIPOTENCY 
Regulation of regeneration in Arabidopsis thaliana
《aBIOTECH》2023年第4期332-351,共20页Md Khairul Islam Sai Teja Mummadi Sanzhen Liu Hairong Wei 
supported by the National Science Foundation Plant Genome Research Program[1703007 to S.L.and H.W]。
We employed several algorithms with high efficacy to analyze the public transcriptomic data,aiming to identify key transcription factors(TFs)that regulate regeneration in Arabidopsis thaliana.Initially,we utilized Col...
关键词：REGENERATION PLURIPOTENCY Transcription factor Collaborative network 
Discordance between chromatin accessibility and transcriptional activity during the human primed-to-naïve pluripotency transition process
《Cell Regeneration》2023年第1期39-51,共13页Zhifen Tu Yan Bi Tengyan Mao Hong Wang Shaorong Gao Yixuan Wang 
supported by the Ministry of Science and Technology of China(2021YFA11020000,2022YFC2702200 and 2018YFA0108900);the National Natural Science Foundation of China(NSFC)(31721003,32022024,32370842,32100633,32270850,32070652 and 81630035);the Shuguang Program of the Shanghai Education Development Foundation and Shanghai Municipal Education Commission(22SG20).
Naive pluripotent state can be obtained by several strategies from various types of cells,in which the cell fate roadmap as well as key biological events involved in the journey have been described in detail.Here,we c...
关键词：Naive pluripotency Primed-to-naïve transition Dual reporter system Discordance between chromatin accessibility and transcriptional activity Histone modifications 
Inhibition of Wnt activity improves peri-implantation development of somatic cell nuclear transfer embryos
《National Science Review》2023年第9期157-173,共17页Yanhe Li Caihong Zheng Yingdong Liu Jincan He Qiang Zhang Yalin Zhang Xiaochen Kou Yanhong Zhao Kuisheng Liu Dandan Bai Yanping Jia Xiaoxiao Han Yifan Sheng Jiqing Yin Hong Wang Shuai Gao Wenqiang Liu Shaorong Gao 
supported by the Ministry of Science and Technology of China(2021YFA1102900);the National Natural Science Foundation of China(31721003,31820103009,82022027,31970814,32270909 and 32200665);supported by the National Key R&D Project of China(2020YFA0113200,2021YFC2700300 and 2018YFC1003102);the 2115 Talent Development Program of China Agricultural University(to S.G.);the Youth Innovation Promotion Association of the Chinese Academy of Sciences(2020104);the Science and Technology Commission of Shanghai Municipality(19JC1415300 and 21JC1405500).
Somatic cell nuclear transfer(SCNT) can reprogram differentiated somatic cells into totipotency.Although pre-implantation development of SCNT embryos has greatly improved,most SCNT blastocysts are still arrested at th...
关键词：SCNT reprogramming implantation WNT naïve pluripotency primed pluripotency EPIBLAST single-cell RNA-seq epigenetic barrier 
Biology and function of pericytes in the vascular microcirculation被引量：1
《Animal Models and Experimental Medicine》2023年第4期337-345,共9页Yue Wu Jiaqi Fu Yuxia Huang Ruowang Duan Wentian Zhang Caihong Wang Shang Wang Xiaoyi Hu Hui Zhao Lan Wang Jinming Liu Guosheng Gao Ping Yuan 
Program of Fundamental Research Funds for the Central Universities,Grant/Award Number:22120220562;Program of Natural Science Foundation of Shanghai,Grant/Award Number:201409004100 and 21ZR1453800;Three Year Action Plan to Promote Clinical Skills and Clinical Innovation in Municipal Hospitals,Grant/Award Number:SHDC2020CR6016-002 and SHDC2020CR4021;Program of Shanghai Pulmonary Hospital,Grant/Award Number:fkzr2320 and FKLY20005。
Pericytes are the main cellular components of tiny arteries and capillaries.Studies have found that pericytes can undergo morphological contraction or relaxation under stimulation by cytokines,thus affecting the contr...
关键词：INFLAMMATION PERICYTES PLURIPOTENCY vascular microcirculatory 
Dual role of lipids for genome stability and pluripotency facilitates full potency of mouse embryonic stem cells
《Protein & Cell》2023年第8期591-602,共12页Liangwen Zhong Miriam Gordillo Xingyi Wang Yiren Qin Yuanyuan Huang Alexey Soshnev Ritu Kumar Gouri Nanjangud Daylon James C.David Allis Todd Evans Bryce Carey Duancheng Wen 
supported by the New York State Stem Cell Science Program under contract C32581GG;the National Institutes of Health under award numbers:1 R01 GM129380-01 and 1R210OD031973-01 (to D.W.).
While Mek1/2 and Gsk3βinhibition("2i")supports the maintenance of murine embryonic stem cells(EsCs)in a homogenous naive state,prolonged culture in 2i results in aneuploidy and DNA hypomethylation that impairs develo...
关键词：mouse pluripotent stem cells LIPIDS pluripotency transition genomic stability developmental potency nucleotide pool depletion 2i medium X chromosome loss femaleall-EsC mice 
The chemical reprogramming of unipotent adult germ cells towards authentic pluripotency and de novo establishment of imprinting
《Protein & Cell》2023年第7期479-498,共20页Yuhan Chen Jiansen Lu Yanwen Xu Yaping Huang Dazhuang Wang Peiling Liang Shaofang Ren Xuesong Hu Yewen Qin Wei Ke Ralf Jauch Andrew Paul Hutchins Mei Wang Fuchou Tang Xiao-Yang Zhao 
supported by grants from the National Key R&D Program of China(2020YFA0113300 to M.W.,2018YFA0107601 to F.T.,2019YFA0801802 to M.W.,2022YFA0806300 to X.-Y.Z.);the National Natural Science Foundation of China(82071711 to X.-Y.Z.,32170866 to M.W.,U22A20278 to X.-Y.Z.);Key Research&Development Program of Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory)(2018GZR110104002 to X.-Y.Z.);Guangdong Basic and Applied Basic Research Foundation(2021A1515010802 to M.W.);National Demonstration Center for Experimental Education of Basic Medical Sciences(Southerm Medical University).
Although somatic cells can be reprogrammed to pluripotent stem cells(PsCs)with pure chemicals,authentic pluripotency of chemically induced pluripotent stem celis(CipsCs)has never been achieved through tetraploid compl...
关键词：REPROGRAMMING spermatogonial stem cell tetraploid complementation IMPRINTING 
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