Biology and function of pericytes in the vascular microcirculation  

作　　者：Yue Wu Jiaqi Fu Yuxia Huang Ruowang Duan Wentian Zhang Caihong Wang Shang Wang Xiaoyi Hu Hui Zhao Lan Wang Jinming Liu Guosheng Gao Ping Yuan 

机构地区：[1]Ningbo University School of Medicine,Ningbo,China [2]Department of Clinical Laboratory,Shanghai Pulmonary Hospital,School of Medicine,Tongji University,Shanghai,China [3]Department of Cardio-Pulmonary Circulation,Shanghai Pulmonary Hospital,School of Medicine,Tongji University,Shanghai,China [4]Institute of Health Science and Engineering,University of Shanghai Science and Technology,Shanghai,China [5]Department of Anesthesiology,Shanghai Pulmonary Hospital,School of Medicine,Tongji University,Shanghai,China [6]Department of Thoracic Surgery,Shanghai Pulmonary Hospital,Tongji University School of Medicine,Shanghai,China [7]Institute of Bismuth Science,University of Shanghai for Science and Technology,Shanghai,China [8]Ningbo Huamei Hospital,University of Chinese Academy of Sciences,Ningbo,China

出　　处：《Animal Models and Experimental Medicine》2023年第4期337-345,共9页动物模型与实验医学（英文）

基　　金：Program of Fundamental Research Funds for the Central Universities,Grant/Award Number:22120220562;Program of Natural Science Foundation of Shanghai,Grant/Award Number:201409004100 and 21ZR1453800;Three Year Action Plan to Promote Clinical Skills and Clinical Innovation in Municipal Hospitals,Grant/Award Number:SHDC2020CR6016-002 and SHDC2020CR4021;Program of Shanghai Pulmonary Hospital,Grant/Award Number:fkzr2320 and FKLY20005。

摘　　要：Pericytes are the main cellular components of tiny arteries and capillaries.Studies have found that pericytes can undergo morphological contraction or relaxation under stimulation by cytokines,thus affecting the contraction and relaxation of microvessels and playing an essential role in regulating vascular microcirculation.Moreover,due to the characteristics of stem cells,pericytes can differentiate into a variety of inflammatory cell phenotypes,which then affect the immune function.Additionally,pericytes can also participate in angiogenesis and wound healing by interacting with endothelial cells in vascular microcirculation disorders.Here we review the origin,biological phenotype and function of pericytes,and discuss the potential mechanisms of pericytes in vascular microcirculation disorders,especially in pulmonary hypertension,so as to provide a sound basis and direction for the prevention and treatment of vascular microcirculation diseases.

关 键 词：INFLAMMATION PERICYTES PLURIPOTENCY vascular microcirculatory 

分 类 号：R543[医药卫生—心血管疾病]