SNORNAS

作品数：15被引量：12H指数：2
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相关领域：生物学更多>>
相关作者：宋现让秦玉蓉陈国宏常洪陈蓉更多>>
相关机构：中山大学山东省肿瘤医院中国农业科学院家禽研究所扬州大学更多>>
相关期刊：《Genes & Diseases》《癌症》《Science Bulletin》《Science China(Life Sciences)》更多>>
相关基金：国家自然科学基金重庆市自然科学基金国家重点基础研究发展计划广东省自然科学基金更多>>
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SnoRNAs: The promising targets for anti-tumor therapy
《Journal of Pharmaceutical Analysis》2024年第11期1588-1602,共15页Xiaoyun Hu Wanlin Cui Min Liu Fangxiao Zhang Yingqi Zhao Mingrong Zhang Yuhang Yin Yalun Li Ying Che Xianglong Zhu Yuxuan Fan Xiaolan Deng Minjie Wei Huizhe Wu 
supported by grants from the National Natural Science Foundation of China(81872905,82272915,and 82073884);the Project of the Fourth Batch of Science and Technology Plan of Liaoning Province,China(Grant No.:2021JH210300133);Science and Technology Innovation Team Project of China Medical University,China(Grant No.:CXTD2022007);the Supporting the Highquality Development of Science and Technology Funding Projects at China Medical University(Grant No.:2022011963-JH2/202);China Postdoctoral Science Foundation(Grant No.:2023MD734246);Liaoning Province Natural Science Foundation Joint Fund(Grant No.:2023-MSLH-396)。
Recently,small nucleolar RNAs(snoRNAs)have transcended the genomic“noise”to emerge as pivotal molecular markers due to their essential roles in tumor progression.Substantial evidence indicates a strong association b...
关键词：SNORNA Cancer snoRNA host gene Multidrug resistance Targeted therapy Tumor immune microenvironment 
Reevaluation by the CRISPR/Cas9 knockout approach revealed that multiple pluripotency-associated lncRNAs are dispensable for pluripotency maintenance while Snora73a/b is essential for pluripotency exit
《Science China(Life Sciences)》2024年第10期2198-2212,共15页Zhen Li Xuefei Li Jingxia Lin Yangming Wang Huiqing Cao Jiajian Zhou 
supported by the National Natural Science Foundation of China(31900447,32070792 and 91940302);the Startup Foundation of Dermatology Hospital,Southern Medical University(2019RC06)。
Many long noncoding RNAs(lncRNAs)have been identified through siRNA-based screening as essential regulators of embryonic stem cell(ESC)pluripotency.However,the biological and molecular functions of most lncRNAs remain...
关键词：long noncoding RNAs embryonic stem cells CRISPR/Cas9 SNORNAS stem cell differentiation 
snoRNAs在肝癌中潜在作用的研究进展
《肿瘤防治研究》2024年第4期284-289,共6页宋馨馨 汪旭 倪娟 
国家自然科学基金(31860301)。
核仁小RNA(snoRNAs)为核仁内存在的一类非编码RNA分子,主要负责rRNA的2′-O-甲基化和假尿嘧啶化修饰。此外,snoRNAs还在tRNA修饰、剪接体snRNA修饰、端粒结构维护及mRNA的可变剪接等生物过程中发挥调控作用。多项研究表明snoRNAs的表达...
关键词：核仁小RNA 肝癌 作用机制 
The emerging role of snoRNAs in human disease被引量：2
《Genes & Diseases》2023年第5期2064-2081,共18页Xinhai Zhang Chenglong Wang Shujun Xia Fei Xiao Jianping Peng Yuxuan Gao Fengbin Yu Chuandong Wang Xiaodong Chen 
supported by the National Natural Science Foundation of China(No.82172473,82072462,81802191);the Natural Science Foundation of Shandong Province,China(No.ZR2019PH068);Public Welfare Basic Research Program of Zhejiang Province,China(No.LY20H060002);2018 Xinhua-uOttawa joint clinical research,China(No.18JX008).
Small nucleolar RNAs(snoRNAs)play critical roles in various biological processes.The aberrant expression or depletion of snoRNAs is related to various diseases.In previous research,most of the snoRNAs were categorized...
关键词：CANCER Genetic disease INFLAMMATION METABOLISM Small nucleolar RNAs 
Comprehensive biological function analysis of lncRNAs in hepatocellular carcinoma被引量：2
《Genes & Diseases》2021年第2期157-167,共11页Dan Wang Fengjiao Chen Tao Zeng Qingxia Tang Bing Chen Ling Chen Yan Dong Xiaosong Li 
This study was supported by the National Natural Science Foundation of China(grant number 81871653),the Program for Innovation Team of Higher Education in Chongqing(grant number CXTDX201601015)and the Natural Science Foundation of Chongqing(grant number cstc2016jcyjA0269).
Thousands of long non-coding RNAs(lncRNAs)have been discovered in human genomes by gene chip,next-generation sequencing,and/or other methods in recent years,which represent a significant subset of the universal genes ...
关键词：ceRNAs HCC lncRNAs MIRNAS ncRNAs SNORNAS 
Small nucleolar RNAs (snoRNAs) as potential non-invasive biomarkers for early cancer detection
《Chinese Journal of Cancer》2013年第2期99-101,共3页Wen-Dan Chen Xiao-Feng Zhu 
Small nucleolar RNAs (snoRNAs) are non-coding RNA (ncRNA) molecules,which are associated with specific proteins to form small nucleolar ribonucleoparticles.However,the function of snoRNAs in cancer still remains elusi...
关键词：核仁小分子RNA 生物标志物 癌症检测 侵入性 非编码RNA 早期 蛋白质 肿瘤 
鹌鹑不同组织中小分子RNA分布规律的初步研究被引量：1
《中国畜牧杂志》2008年第21期7-9,共3页常国斌 刘向萍 常洪 秦玉蓉 陈蓉 陈国宏 
国家自然科学基金项目(30700564)
小分子非编码RNA可分为miRNAs、piRNAs和snoRNAs3种类型。选用雄性鹌鹑20只,分别采集心脏、肝脏、肾脏和睾丸组织,提取小分子RNA,分析不同组织中各种小分子RNA的表达形式和分布规律。结果表明:miRNAs的表达存在组织差异性,在肝脏、肾脏...
关键词：小分子RNA MIRNAS piRNAs SNORNAS 鹌鹑 
Identification and evolution-ary implication of four novel box H/ACA snoRNAs from Giardia lamblia
《Chinese Science Bulletin》2006年第20期2451-2456,共6页LUO Jun ZHOU Hui CHEN Chongjian LI Yan CHEN Yueqin QU Lianghu 
the National Natural Science Foundation of China （Grant Nos. 30230200 ＆ 30370328）; the funds from the Ministry of Education of China and Natural Science Foundation of Guangdong Province （Grant No. IRT0447, NSF-05200303）; the National Basic Research Program （Grant No. 2005CB724600）.
From a specialized cDNA library, four novel box H/ACA snoRNAs, named GLsR22, GLsR23, GLsR24 and GLsR25, were identified from the primitive eukaryote, Giardia lamblia. Bioinformat- ics analyses indicated that all of th...
关键词：贾第虫 兰氏鞭毛虫 基因工程 核糖核酸 
Identification and characterization of two novel box H/ACA snoRNAs from Schizosaccharomyces pombe
《Progress in Natural Science:Materials International》2005年第6期507-514,共8页LISiguang ZHOUHui ZHANGPeng LUOYuping QULianghu 
SupportedbyNationalNaturalScienceFoundationofChina(GrantNos.30230200and30170216)
Through constructing a specialized cDNA library based on small RNAs isolated from partial purified nuclei of Schizosaccharomyces pombe, two novel noncoding RNAs, termed Sp15-70 and Sp18-61, have been identified. Bioin...
关键词：box H/ACA snoRNA RNA pseudouridylation gene evolution Schizosaccharomyces pombe 
名至实归的RNAi技术
《生物技术世界》2005年第08M期12-13,共2页
仿佛一夜之间，被科学家遗忘的RNA取代了DNA、成为研究热点，尤其是RNAi,备受瞩目，许多生物学家都支持“RNA是最早的生命和遗忘物质”的理论。就在我们编辑这期专题的时候，还不断的有相关文章，报道问世。
关键词：RNA干扰(RNAI) 微小RNA(miRNAs) 信使RNA(mRNA) 发夹RNAs(shRNAs) 双链RNAs(dsRNAs) 小分子干扰RNA(siRNA) 小分子细胞核RNAs(snoRNAs) RNAI技术 研究热点 生物学家 
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