EPIBLAST

作品数：12被引量：16H指数：3
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相关领域：生物学更多>>
相关机构：昆明理工大学更多>>
相关期刊：《Science China(Life Sciences)》《World Journal of Stem Cells》《National Science Review》《Cell Regeneration》更多>>
相关基金：国家自然科学基金北京市自然科学基金更多>>
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Sex differences in human pre-gastrulation embryos
《Science China(Life Sciences)》2025年第2期397-415,共19页Yongjie Lu Meng Qin Xintong Qi Ming Yang Fan Zhai Jiaqi Zhang Zhiqiang Yan Liying Yan Jie Qiao Peng Yuan 
funded by grants from the National Key Research and Development Program(2019YFA0110001 and 2022YFC2702200);the National Natural Science Foundation of China(82288102,82125013,82201838,and 82101677);the Young Elite Scientists Sponsorship Program by China Association for Science and Technology(YESS20200398)。
Human fetuses exhibit notable sex differences in growth rate and response to the intrauterine environment,yet their origins and underlying mechanisms remain uncertain.Here,we conduct a detailed investigation of sex di...
关键词：human embryo sex difference TROPHECTODERM primitive endoderm EPIBLAST 
Inhibition of Wnt activity improves peri-implantation development of somatic cell nuclear transfer embryos
《National Science Review》2023年第9期157-173,共17页Yanhe Li Caihong Zheng Yingdong Liu Jincan He Qiang Zhang Yalin Zhang Xiaochen Kou Yanhong Zhao Kuisheng Liu Dandan Bai Yanping Jia Xiaoxiao Han Yifan Sheng Jiqing Yin Hong Wang Shuai Gao Wenqiang Liu Shaorong Gao 
supported by the Ministry of Science and Technology of China(2021YFA1102900);the National Natural Science Foundation of China(31721003,31820103009,82022027,31970814,32270909 and 32200665);supported by the National Key R&D Project of China(2020YFA0113200,2021YFC2700300 and 2018YFC1003102);the 2115 Talent Development Program of China Agricultural University(to S.G.);the Youth Innovation Promotion Association of the Chinese Academy of Sciences(2020104);the Science and Technology Commission of Shanghai Municipality(19JC1415300 and 21JC1405500).
Somatic cell nuclear transfer(SCNT) can reprogram differentiated somatic cells into totipotency.Although pre-implantation development of SCNT embryos has greatly improved,most SCNT blastocysts are still arrested at th...
关键词：SCNT reprogramming implantation WNT naïve pluripotency primed pluripotency EPIBLAST single-cell RNA-seq epigenetic barrier 
Author Correction:Formative pluripotent stem cells show OPEN features of epiblast cells poised for gastrulation
《Cell Research》2022年第9期866-866,共1页
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License,which permits use,sharing,adaptation,distribution and reproduction in any medium or format,as long as you give approp...
关键词：Forma LICENSE FEATURES 
Transcriptomic profiling fuels the derivation of stable pig epiblast stem cells
《Cell Research》2022年第4期329-330,共2页Cuiqing Zhong Ronghui Li Juan Carlos lzpisua Belmonte 
It is controversial whether pig pluripotent stem cells can be derived and stably maintained in a culture dish.In a recent paper published in Cell Research,Zhi et al.perform a comprehensive transcriptome landscape anal...
关键词：culture maintained LANDSCAPE 
Generation and characterization of stable pig pregastrulation epiblast stem cell lines被引量：7
《Cell Research》2022年第4期383-400,共18页Minglei Zhi Jinying Zhang Qianzi Tang Dawei Yu Shuai Gao Dengfeng Gao Pengliang Liu Jianxiong Guo Tang Hai Jie Gao Suying Cao Zimo Zhao Chongyang Li Xiaogang Weng Mengnan He Tianzhi Chen Yingjie Wang Keren Long Deling Jiao Guanglei Li Jiaman Zhang Yan Liu Yu Lin Daxin Pang Qianqian Zhu Naixin Chen Jingjing Huang Xinze Chen Yixuan Yao Jingcang Yang Zicong Xie Xianya Huang Mengxin Liu Ran Zhang Qiuyan Li Yiliang Miao Jianhui Tian Xingxu Huang Hongsheng Ouyang Bofeng Liu Wei Xie Qi Zhou Zhonghua Liu Caihong Zheng Mingzhou Li Jianyong Han 
supported by the National Key R&D Program of China(2016YFA0100202,2016YFA0100200,2020YFA0509500,2019YFA0110700,2019YFA0110702,2020YFA0113200,2018YFC1003102,2017YFC0908402);the National Natural Science Foundation of China(31970825,31772601,31601941,31571497,U19A2036,31772576);Beijing Natural Science Foundation(6192005);Plan 111(B12008),the Youth Innovation Promotion Association of Chinese Academy of Sciences(2020104,2021081);Research Programs from the State Key Laboratories for Agro-biotechnology;China Agricultural University(2020SKLAB1-3,2021SKLAB6-6);the Science and Technology Program of Sichuan(2021YFYZ0009),and Yunling Scholars Program of Yunnan Province.
Pig epiblast-derived pluripotent stem cells are considered to have great potential and broad prospects for human therapeutic model developme nt and livestock breeding.Despite on going attempts since the 1990s,no stabl...
关键词：HUSBANDRY MAINTAIN successive 
Zfp281 is essential for epiblast maturation through a cell autonomous effect
《Journal of Genetics and Genomics》2022年第1期85-88,共4页Ruge Zang Xin Huang Dan Li Hongwei Zhou Shaorong Gao Jianlong Wang 
funded by grants from the National Institutes of Health (R01GM129157, R01HD095938, R01HD097268, and R01HL146664);by contracts from New York State Stem Cell Science (NYSTEM#C35583GG and C35584GG)。
Pluripotency is recognized as a spectrum of cellular states spanning the na?ve pluripotency established in the preimplantation blastocyst and its transition into primed pluripotency in the postimplantation epiblast ce...
关键词：IMPLANTATION AUTONOMOUS EFFECT 
Formative pluripotent stem cells show features of epiblast cells poised for gastrulation被引量：6
《Cell Research》2021年第5期526-541,共16页Xiaoxiao Wang Yunlong Xiang Yang Yu Ran Wang Yu Zhang Qianhua Xu Hao Sun Zhen-Ao Zhao Xiangxiang Jiang Xiaoqing Wang Xukun Lu Dandan Qin Yujun Quan Jiaqi Zhang Ng Shyh-Chang Hongmei Wang Naihe Jing Wei Xie Lei Li 
The study was supported by the National Key R&D Program of China(2018YFC1004500,2017YFC1001401,2019YFA0508900);the National Natural Science Foundation of China(31930033,31590832,31988101,31725018).
The pluripotency of mammalian early and late epiblast could be recapitulated by naïve embryonic stem cells(ESCs)and primed epiblast stem cells(EpiSCs),respectively.However,these two states of pluripotency may not be s...
关键词：PLURIPOTENT FEATURES development. 
Pluripotent stem cells secrete Activin A to improve their epiblast competency after injection into recipient embryos被引量：1
《Protein & Cell》2018年第8期717-728,共12页Jinzhu Xiang Suying Cao Liang Zhong Hanning Wang Yangli Pei Qingqing Wei Bingqiang Wen Haiyuan Mu Shaopeng Zhang Liang Yue Genhua Yue Bing Lim Jianyong Han 
This work was supported by The National Key Research and Development Program of China （2016YFA0100202）, National Nat- ural Science Foundation of China （Grant Nos. 31571497 and31601941 ）, Beijing Natural Science Foundation of China （6152004）, The National Thousand Talents Program of China and Research Programs from the State Key Laboratory for Agrobiotechnology, China Agricultural University （grant numbers 2015SKLAB1-4, 2017SKLAB1-2）.
It is not fully clear why there is a higher contribution of pluripotent stem cells （PSCs） to the chimera produced by injection of PSCs into 4-cell or 8-cell stage embryos compared with blastocyst injection. Here, we...
关键词：pluripotent stem cells 4-cell embryoinjection secreted proteins Activin A chimeric mice 
Ectodermal progenitors derived from epiblast stem cells by inhibition of Nodal signaling
《Journal of Molecular Cell Biology》2015年第5期455-465,共11页Lingyu Li Lu Song Chang Liu Jun Chen Guangdun Peng Ran Wang Pingyu Liu Ke Tang Janet Rossant Naihe Jing 
Thisworkwas supported in part by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA01010201);the National Key Basic Research and Development Program of China(2014CB964804,2015CB964500);the National Natural Science Foundation of China(91219303,31430058).
The ectoderm has the capability to generate epidermis and neuroectoderm and plays imperative roles during the early embryonic development.Our recent study uncovered a region with ectodermal progenitor potential in mou...
关键词：EpiSCs ECTODERM BMP4 NODAL FGF 
Durable pluripotency and haploidy in epiblast stem cells derived from haploid embryonic stem cells in vitro被引量：1
《Journal of Molecular Cell Biology》2015年第4期326-337,共12页Ling Shuai Yukai Wang Mingzhu Dong Xuepeng Wang Lisi Sang Mei Wang Haifeng Wan Guanzheng Luo Tiantian Gu Yan Yuan Chunjing Feng Fei Teng Wei Li Xiuying Liu Tianda Li Liu Wang Xiu-Jie Wang Xiao-Yang Zhao Qi Zhou 
supported by grants from the National Basic Research Program of China(2012CBA01300 to Q.Z.and 2014CB964800 to W.L.);the National Science Foundation of China(91319308 to Q.Z.).
Haploid pluripotent stem cells,such as haploid embryonic stem cells(haESCs),facilitate the genetic study of recessive traits.In vitro,fish haESCs maintain haploidy in both undifferentiated and differentiated states,bu...
关键词：HAPLOID epiblast stem cells durable pluripotency 
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