ECTODERM

作品数：9被引量：18H指数：3
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Docking and 3D-QSAR Studies on the Imidazo[1,5-c]pyrimidine Derivative as EED Inhibitors
《Chinese Journal of Structural Chemistry》2021年第6期689-702,683,共15页CHEN Xiao-Zhong LI Guang-Ping SHEN Yan HU Yong WANG Juan WANG Yuan-Qiang LIN Zhi-Hua 
supported by the National Natural Science Foundation of China (81171508);Key project of Chongqing
Embryonic ectoderm development(EED)has become a novel target for cancer treatment.In this study,a series of EED inhibitors was subjected to a three-dimensional quantitative structure-activity relationship(3D-QSAR)and ...
关键词：embryonic ECTODERM development COMFA COMSIA molecular DOCKING 
Role of Smad4 from ocular surface ectoderm in retinal vasculature development被引量：2
《International Journal of Ophthalmology(English edition)》2020年第2期231-238,共8页Jing Li Jin-Song Zhang Jiang-Yue Zhao Guo-Ge Han 
Supported by Tianjin Natural Science Funds(No.18JCQNJC10600).
●AIM:To investigate how signals from lens regulate retinal vascular development and neovascularization.●METHODS:Le-Cre transgenic mouse line was employed to inactivate Smad4 in the surface ectoderm selectively.Stand...
关键词：SMAD4 RETINAL VASCULATURE SURFACE ECTODERM 
Tonsil-derived stem cells as a new source of adult stem cells被引量：3
《World Journal of Stem Cells》2019年第8期506-518,共13页Kyung-Ah Cho Hyun Jung Lee Hansaem Jeong Miri Kim Soo Yeon Jung Hae Sang Park Kyung-Ha Ryu Seung Jin Lee Byeongmoon Jeong Hyukjin Lee Han Su Kim 
Supported by the Korea Health Technology RD Project through the Korea Health Industry Development Institute;the Ministry of Health and Welfare,No.HI16C-2207;the Basic Science Research Program through the NRF,No.NRF-2018R1D1A1A09083264;Ewha Womans University,No.RP-grant2017
Located near the oropharynx, the tonsils are the primary mucosal immune organ. Tonsil tissue is a promising alternative source for the high-yield isolation of adult stem cells, and recent studies have reported the ide...
关键词：STEM CELL Tonsil-derived STEM CELL Differentiation ENDODERM Mesoderm ECTODERM CELL therapy 
Studying developmental neurotoxic effects of bisphenol A(BPA) using embryonic stem cells被引量：6
《Journal of Environmental Sciences》2015年第10期173-177,共5页Jinhua Li Katherine Z.Fu Sai Vemula X.Chris Le Xing-Fang Li 
the Canada Research Chairs Program,the Canadian Institutes of Health Research,and the Natural Sciences and Engineering Research Council of Canada for their support
There is little to no toxicity information regarding thousands of chemicals to which people are exposed daily.In fact,of the84,000 chemicals listed in the United States Toxic Substances Control Act Inventory,there is ...
关键词：Bisphenol A（BPA） Embryonic stem cells（ESCs） Embryoid bodies（EBs） Environmental toxicology Developmental toxicity Neural ectoderm Neural progenitor cells（NPCs） Neurotoxicity 
Assessment of Bisphenol A(BPA) neurotoxicity in vitro with mouse embryonic stem cells被引量：10
《Journal of Environmental Sciences》2015年第10期181-187,共7页Nuoya Yin Xinglei Yao Zhanfen Qin Yuan-Liang Wang Francesco Faiola 
supported by a Chinese Academy of Sciences(CAS)Strategic Leading Science&Technology Program grant(XDB14040301);by the Hundred Talent Program of CAS(121311ZXPP2014004)at the Research Center for Eco-Environmental Sciences(RCEES),CAS
The adverse effects of environmental pollution on our well-being have been intensively studied with many in vitro and in vivo systems. In our group, we focus on stem cell toxicology due to the multitude of embryonic s...
关键词：Bisphenol A（BPA） Stem cell toxicology Neurotoxicity Embryonic stem cells（ESCs） Developmental toxicity Neural ectoderm 
Kindler syndrome protein Kindlin-1 is mainly expressed in adult tissues originating from ectoderm/endoderm被引量：1
《Science China(Life Sciences)》2015年第5期432-441,共10页ZHAN Jun YANG Mei ZHANG Jing GUO YongQing LIU Wei ZHANG HongQuan 
supported by the National Natural Science Foundation of China(81301802,81230051,30830048,31170711);Grant of Ministry of Science and Technology of China(2013CB910501,2010CB912203,2010CB529402);Program for Introducing Talents of Discipline to Universities(111 Project)of Ministry of Education;Beijing Natural Science Foundation(7120002);Peking University grants(BMU20120314,BMU20130364,BMU20130373);a Leading Academic Discipline Project of Beijing Education Bureau
Mutations of integrin-interacting protein Kindlin-1 cause Kindler syndrome and deregulation of Kindlin-1 is implicated in human cancers. The Kindlin-1-related diseases are confined in limited tissue types. However, Ki...
关键词：Kindlin- 1 epithelial tissue ECTODERM ENDODERM embryo 
Ectodermal progenitors derived from epiblast stem cells by inhibition of Nodal signaling
《Journal of Molecular Cell Biology》2015年第5期455-465,共11页Lingyu Li Lu Song Chang Liu Jun Chen Guangdun Peng Ran Wang Pingyu Liu Ke Tang Janet Rossant Naihe Jing 
Thisworkwas supported in part by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA01010201);the National Key Basic Research and Development Program of China(2014CB964804,2015CB964500);the National Natural Science Foundation of China(91219303,31430058).
The ectoderm has the capability to generate epidermis and neuroectoderm and plays imperative roles during the early embryonic development.Our recent study uncovered a region with ectodermal progenitor potential in mou...
关键词：EpiSCs ECTODERM BMP4 NODAL FGF 
Ni^(2+) treatment causes cement gland formation in ectoderm explants of Xenopus laevis embryo
《Cell Research》1999年第1期71-76,共6页HUANGYONG XIAOYANDING 
We found T-type calcium channel blocker Ni2+ can efficiently induce the formation of cement gland in Xenopus laevis animal cap explants. Another T-type specific calcium channel blocker Amiloride can also induce the fo...
关键词：Ni^(2+) cement gland GASTRULATION T-type calcium channel 
Developmental potency of mouse primitive ectoderm cells, embryonic ectoderm cells and primordial germ cells after blastocyst injection
《Cell Research》1990年第1期53-65,共13页Shen SanbingInstitute of Developmental Biology,Academia Sinica,Beijing, China 
Developmental potency of primitive and embryonic ectoderm cells from 4.50-day to 6.25-day post-coitum (p.c.) mouse embryos and primordial germ cells from 12.50-day p.c.male genital ridges of fetal mice were studied by...
关键词：developmental potency primitive ectoderm cells embryonic ectoderm cells primordial germ cells blastocyst injection pluripolenl stem cell origin. 
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