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作品数：10被引量：28H指数：3
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Human endoderm stem cells reverse inflammation-related acute liver failure through cystatin SN-mediated inhibition of interferon signaling被引量：1
《Cell Research》2023年第2期147-164,共18页Yilin Xu Jinglin Wang Haozhen Ren Hao Dai Ying Zhou Xiongzhao Ren Yang Wang Sisi Feng Xiaogang Deng Jiaying Wu Tianlong Fu Tengfei Nie Haifeng He Tongkun Wei Bing Zhu Lijian Hui Bin Li Jing Wang Hongyan Wang Luonan Chen Xiaolei Shi Xin Cheng 
National Key R&D Program of China(2017YFA0102702);“Strategic Priority Research Program”of the Chinese Academy of Sciences(XDA16020203);National Natural Science Foundation of China(82100664,82270646);National Key R&D Program of China(2017YFA0504501);Scientific Instrument Developing Project of the Chinese Academy of Sciences(YJKYYQ20170042);National Natural Science Foundation of China(31771061);Science and Technology Commission of Shanghai Municipality(15JC1400201);Jiangsu Province’s Key Provincial Talents Program(ZDRCA2016066);Certificate of China Postdoctoral Science Foundation Grant(2018M642222);Jiangsu Province Natural Science Foundation(BK20190114);Nanjing Medical Science and Technique Development Foundation(QRX17129);Nanjing Health Science and Technology Development Project for Distinguished Young Scholars(JQX19002,JQX22003);Jiangsu Province Postdoctoral Research Funding Program(2021K116B);Nanjing Health Science and Technology Development Project for Medical and Health Research(YKK19070);Nanjing Science and Technology Project(201911039);Innovation and Entrepreneurship Education Incubation Project of Nanjing University;Fundamental Research Funds for the Central Universities(0214-14380510);Project of Modern Hospital Management and Development Institute,Nanjing University and Aid project of Nanjing Drum Tower Hospital Health,Education&Research Foundation(NDYG2020047,NDYG2022057);fundings for Clinical Trials from the Affiliated Drum Tower Hospital,Medical School of Nanjing University(2021-LCYJ-PY-46,2022-LCYJ-PY-35);Chen Xiao-ping Foundation for the Development of Science and Technology of Hubei Province,China(CXPJJH121001-2021073,CXPJJH122002-019).
Acute liver failure(ALF)is a life-threatening disease that occurs secondary to drug toxicity,infection or a devastating immune response.Orthotopic liver transplantation is an effective treatment but limited by the sho...
关键词：INFLAMMATION ORGANS DONOR 
Correction to: ZFP281 recruits polycomb repressive complex 2 to restrict extraembryonic endoderm potential in safeguarding embryonic stem cell pluripotency
《Protein & Cell》2021年第6期511-513,共3页Xin Huang Nazym Bashkenova Jihong Yang Dan Li Jianlong Wang 
CORRECTION TO:PROTEIN CELL HTTPS://DOI.ORG/10.1007/S13238-020-00775-X In the original publication the labelling in middle and bottom panels of Fig.2K is published incorrectly as“Soc17”.The correct labeling is availa...
关键词：CORRECTION restrict POTENTIAL 
ZFP281 recruits polycomb repressive complex 2 to restrict extraembryonic endoderm potential in safeguarding embryonic stem cell pluripotency
《Protein & Cell》2021年第3期213-219,共7页Xin Huang Nazym Bashkenova Jihong Yang Dan Li Jianlong Wang 
We thank Dr.Philippe Soriano for providing the XENB1 cell line.Research in Wang laboratory was funded by grants from the NIH(R01GM129157,R01HD095938,and R01HD097268)and NYSTEM(C32583GG and C32569GG).
Dear Editor,Cell-fate decisions are governed by comprehensive generegulatory programs.During the preimplantation development,at least two waves of cell fate decisions are made while the cells gradually lose their toti...
关键词：restrict implantation SORTING 
Modeling endodermal organ development and diseases using human pluripotent stem cell-derived organoids被引量：1
《Journal of Molecular Cell Biology》2020年第8期580-592,共13页Fong Cheng Pan Todd Evans Shuibing Chen 
Recent advances in development of protocols for directed differentiation from human pluripotent stem cells(hPSCs)to defined lineages,in combination with 3D organoid technology,have facilitated the generation of variou...
关键词：human pluripotent stem cells ENDODERM gastrointestinal development disease modeling 
Tonsil-derived stem cells as a new source of adult stem cells被引量：3
《World Journal of Stem Cells》2019年第8期506-518,共13页Kyung-Ah Cho Hyun Jung Lee Hansaem Jeong Miri Kim Soo Yeon Jung Hae Sang Park Kyung-Ha Ryu Seung Jin Lee Byeongmoon Jeong Hyukjin Lee Han Su Kim 
Supported by the Korea Health Technology RD Project through the Korea Health Industry Development Institute;the Ministry of Health and Welfare,No.HI16C-2207;the Basic Science Research Program through the NRF,No.NRF-2018R1D1A1A09083264;Ewha Womans University,No.RP-grant2017
Located near the oropharynx, the tonsils are the primary mucosal immune organ. Tonsil tissue is a promising alternative source for the high-yield isolation of adult stem cells, and recent studies have reported the ide...
关键词：STEM CELL Tonsil-derived STEM CELL Differentiation ENDODERM Mesoderm ECTODERM CELL therapy 
Kindler syndrome protein Kindlin-1 is mainly expressed in adult tissues originating from ectoderm/endoderm被引量：1
《Science China(Life Sciences)》2015年第5期432-441,共10页ZHAN Jun YANG Mei ZHANG Jing GUO YongQing LIU Wei ZHANG HongQuan 
supported by the National Natural Science Foundation of China(81301802,81230051,30830048,31170711);Grant of Ministry of Science and Technology of China(2013CB910501,2010CB912203,2010CB529402);Program for Introducing Talents of Discipline to Universities(111 Project)of Ministry of Education;Beijing Natural Science Foundation(7120002);Peking University grants(BMU20120314,BMU20130364,BMU20130373);a Leading Academic Discipline Project of Beijing Education Bureau
Mutations of integrin-interacting protein Kindlin-1 cause Kindler syndrome and deregulation of Kindlin-1 is implicated in human cancers. The Kindlin-1-related diseases are confined in limited tissue types. However, Ki...
关键词：Kindlin- 1 epithelial tissue ECTODERM ENDODERM embryo 
Endoderm contributes to endocardial composition during cardiogenesis
《Chinese Science Bulletin》2014年第22期2749-2755,共7页Yan Li Xiaoyu Wang Zhenglai Ma Manli Chuai Andrea Münsterberg Kenneth KaHo Lee Xuesong Yang 
supported by the National Natural Science Foundation of China (30971493, 31071054);the National Basic Research Program of China (2010CB529703)
Heart formation commences from a single heart tube,which fuses from bilateral primordial heart fields.The developing heart tube is composed of outer-layer myocardial cells and inner-layer endocardial cells.Several dis...
关键词：心内膜 心脏 胚层 原肠胚期 组成 心肌细胞 数据显示 膜细胞 
Maternal Eomesodermin regulates zygotic nodal gene expression for mesendoderm induction in zebrafish embryos被引量：5
《Journal of Molecular Cell Biology》2014年第4期272-285,共14页Pengfei Xu Gaoyang Zhu Yixia Wang Jiawei Sun Xingfeng Liu Ye-Guang Chen Anming Meng 
Acknowledgements We thank Drs Alex Schier and Susan Mango （Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA） for discussion and suggestions, Dr David Kimelman （Department of Biochemistry, University of Washington, Seattle, WA, USA） for myc-eomesa construct, and members of the Meng lab for discussion and technical assistance. This work was financially supported by grants from the Major Science Research Programs of China （2011CB943800） and the National Natural Science Foundation of China （31221064）.
Development of animal embryos before zygotic genome activation at the mid blastula transition （MBT） is essentially supported by eggderived maternal products. Nodal proteins are crucial signals for mesoderm and endod...
关键词：EOMESODERMIN NODAL transcription MESODERM ENDODERM EMBRYO zebrafish 
Liver development in zebrafish (Danio rerio)被引量：17
《Journal of Genetics and Genomics》2009年第6期325-334,共10页Ting Tao Jinrong Peng 
supported by the National Natural Science Foundation of China (No. 30825025)
Liver is one of the largest internal organs in the body and its importance for metabolism, detoxification and homeostasis has been well established. In this review, we summarized recent progresses in studying liver in...
关键词：ZEBRAFISH model organism liver development ENDODERM 
Roles of the Nanog protein in murine F9 embryonal carcinoma cells and their endoderm-differentiated counterparts
《Cell Research》2006年第7期641-650,共10页Yanmei Chen Zhongwei Du Zhen Yao 
Nanog is a recently discovered homeodomain transcription factor that sustains the pluripotency of embryonic stem （ES） cells and blocks their differentiation into endoderm. The murine F9 embryonal carcinoma cell line...
关键词：NANOG F9 embryonal carcinoma cells ENDODERM differentiation 
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