MESODERM

作品数：15被引量：25H指数：4
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相关期刊：《Acta Biochimica et Biophysica Sinica》《Science China(Life Sciences)》《Acta Pharmacologica Sinica》《World Journal of Stem Cells》更多>>
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Identification and characterization of human hematopoietic mesoderm被引量：1
《Science China(Life Sciences)》2024年第2期320-331,共12页Yuqi Wen Jingjing Zhao Runqing Zhang Fan Liu Xiaoyuan Chen Dan Wu Mengge Wang Cuicui Liu Pei Su Panpan Meng Yiyue Zhang Xin Gao Lu Wang Hongtao Wang Jiaxi Zhou 
supported by the CAMS Innovation Fund for Medical Sciences(2021-I2M-1-073,2021-I2M-1-040,2022-I2M-JB-015);the National Key Research and Development Program of China(2021YFA1100703,2021YFA1103000);Haihe Laboratory of Cell Ecosystem Innovation Fund(22HHXBSS00031);the National Natural Science Foundation of China(82125003,32271161,82200141);Tianjin Municipal Science and Technology Commission Grant(20JCYBJC00240,22ZXSYSY00010,22JCQNJC01270)。
The embryonic mesoderm comprises heterogeneous cell subpopulations with distinct lineage biases.It is unclear whether a bias for the human hematopoietic lineage emerges at this early developmental stage.In this study,...
关键词：hematopoietic mesoderm human pluripotent stem cells human embryos BMP4 HDAC1 
CTCF acetylation at lysine 20 is required for the early cardiac mesoderm differentiation of embryonic stem cells
《Cell Regeneration》2022年第1期348-364,共17页Shixin Gong Gongcheng Hu Rong Guo Jie Zhang Yiqi Yang Binrui Ji Gang Li Hongjie Yao 
This work was supported in part by grants from the National Key R&D Program of China(2021YFA1100300);Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16010502);National Natural Science Foundation of China(31925009,U21A20195,32000424,32100462,32100463,and 81902885);Science and Technology Planning Project of Guangdong Province,China(2019B020234004,2019A050510004 and 2020B1212060052);Macao Science and Technology Development Fund(FDCT0107/2019/A2).
The CCCTC-binding factor(CTCF)protein and its modified forms regulate gene expression and genome organization.However,information on CTCF acetylation and its biological function is still lacking.Here,we show that CTCF...
关键词：CTCF CTCF acetylation CBP HDAC6 Early cardiac mesoderm differentiation 
Overexpression of HOXA9 upregulates NF-κB signaling to promote human hematopoiesis and alter the hematopoietic differentiation potentials
《Cell Regeneration》2021年第1期95-106,共12页Jiahui Zeng Danying Yi Wencui Sun Yuanlin Liu Jing Chang Lijiao Zhu Yonggang Zhang Xu Pan Yong Dong Ya Zhou Mowen Lai Guohui Bian Qiongxiu Zhou Jiaxin Liu Bo Chen Feng Ma 
This work was supported by awards from the CAMS Initiatives for Innovative Medicine(2016-I2M-1-018 to F.Ma and 2017-I2M-3-021 to J.X.Liu);Sichuan Provincial Science and Technology Department Key R&D projects(020YFSY0023 to B.Chen);the Chengdu Science and Technology Project-Technology Innovation R&D(2018-YF05-01341-SN to B.Chen).
Background: The HOX genes are master regulators of embryogenesis that are also involved inhematopoiesis. HOXA9 belongs to a cluster of HOX genes that play extensively studied roles inhematopoiesis and leukemogenesis.M...
关键词：HEMATOPOIESIS Differentiation of hematopoietic lineages HOXA9 MESODERM Human embryonic stem cells(hESCs) TET-ON Inducible expression system 
Zichong granules(资冲颗粒)promote differentiation of ovarian granulosa-like cells from human embryonic stem cells in vitro
《Journal of Traditional Chinese Medicine》2021年第2期203-211,共9页YAO Zouying WANG Jing LU Hua LI Limin ZHUO Tianxiu WAN Qian YIE Shangmian 
Supported by The National Basic Research Program of China:Study on the theory of"kidney governs reproduction"from the perspective of infertility(973 Plan,Grant Nos.2010CB530403 and 2010CB530400)。
OBJECTIVE:To investigate whether Zichong granules(资冲颗粒,ZCKL),a very effective herbal formula for treating infertility,have an impact on the differentiation of ovarian granulosa cells from human embryonic stem cell...
关键词：human embryonic stem cells INFERTILITY serum MESODERM OVARIAN granulosa cells Zichong granules 
Mass acquisition of human periodontal ligament stem cells被引量：4
《World Journal of Stem Cells》2020年第9期1023-1031,共9页Hidefumi Maeda 
Supported by Japan Society for the Promotion of Science,No.JP17H01598.
The periodontal ligament(PDL)is an essential fibrous tissue for tooth retention in the alveolar bone socket.PDL tissue further functions to cushion occlusal force,maintain alveolar bone height,allow orthodontic tooth ...
关键词：Induced pluripotent stem cells Mesoderm specific transcript Periodontal ligament stem cells Periodontal tissue Regenerative medicine Semaphorin 3A 
RUNX1-205, a novel splice variant of the human RUNX1 gene, has blockage effect on mesoderm-hemogenesis transition and promotion effect during the late stage of hematopoiesis
《Journal of Molecular Cell Biology》2020年第5期386-396,共11页Wencui Sun Jiahui Zeng Jing Chang Yuan Xue Yonggang Zhang Xu Pan Ya Zhou Mowen Lai Guohui Bian Qiongxiu Zhou Jiaxing Liu Bo Chen Feng Ma 
supported by grants from the CAMS Initiatives for Innovative Medicine(2016-I2M-1-018 to F.M.and 2017-I2M-3-021 to J.L.);the Sichuan Provincial Health and Family Planning Commissi on research project(17PJ489 to B.C.);Chengdu Science and Technology Project-Technology Innovation R&D(2018-YF05-01341-SN to B.C.).
Runt-related transcription factor 1(RUNX1)is required for definitive hematopoiesis;however,the functions of most human RUNX1 isoforms are unclear.In particular,the effects of RUNX1-205(a novel splice variant that lack...
关键词：mesoderm-hemogenesis TRANSITION HEMATOPOIESIS hematopoietic stem/progenitor CELLS (HSPCs) RUNX1 MESODERM embryonic STEM CELLS (ESCs) 
Mitochondrial metabolism and glutamine are essential for mesoderm differentiation of human pluripotent stem cells
《Cell Research》2019年第7期596-598,共3页Vivian Lu Perrine Dahan Fasih M. Ahsan Alexander N. Patananan Irena J. Roy Alejandro Torres Jr Robert M. T. Nguyen Dian Huang Daniel Braas Michael A. Teitell 
Human pluripotent stem cells (hPSCs) generate energy mainly by aerobic glycolysis, with glutamine oxidation in the tricarboxylic acid (TCA) cycle providing additional ATP required for survival.1,2,3 During the exit fr...
关键词：cells AEROBIC CONSENSUS 
A Linc1405/Eomes complex promotes cardiac mesoderm specification and cardiogenesis被引量：1
《Science Foundation in China》2018年第2期21-21,共1页
With the support by the National Natural Science Foundation of China,the research term directed by Prof.Kang JiuHong(康九红)at the Shanghai Key Laboratory of Signaling and Disease Research,Collaborative Innovation Cen...
关键词：建筑群 中层 心脏 
Effect of MEST on the angiogenesis and trophoblast cell invasion in the preeclampsia placenta
《Journal of Hainan Medical University》2017年第23期58-61,共4页Xiu-Qiong Zhang Yu-Qin Liu 
Objective: To study the effect of mesoderm-specific transcript (MEST) on the angiogenesis and trophoblast cell invasion in the preeclampsia placenta. Methods: The puerperae who were diagnosed with preeclampsia and gav...
关键词：PREECLAMPSIA Mesoderm-specific TRANSCRIPT ANGIOGENESIS Cell invasion 
Inducible overexpression of RUNX1b/c in human embryonic stem cells blocks early hematopoiesis from mesoderm被引量：4
《Journal of Molecular Cell Biology》2017年第4期262-273,共12页Bo Chen Jiawen Teng Hongwei Liu Xu Pan Ya Zhou Shu Huang Mowen Lai Guohui Bian Bin Mao Wencui Sun Qiongxiu Zhou Shengyong Yang Tatsutoshi Nakahata Feng Ma 
This work was supported by the National Program on Key Basic Research Project of China （973 Program; 2015CB964902）, the National Natural Science Foundation of China （NSFC; H81170466 and H81370597）, and the CAMS Initiatives for Innovative Medicine （2016-12M-1-018） awarded to F.M.
RUNXI is absolutely required for definitive hematopoiesis, but the function of RUNXlb/c, two isoforms of human RUNX1, is unclear. We established inducible RUNXlb/c-overexpressing human embryonic stem cell （hESC） lin...
关键词：RUNX1/AML1 HEMATOPOIESIS hemogenic endothelium MESODERM TGF-β signaling pathway HESC inducible expressionsystem 
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