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作品数：163被引量：415H指数：9
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相关领域：医药卫生农业科学更多>>
相关作者：陆丽丽刘丹赵艳敏饶纯倪毅然更多>>
相关机构：内蒙古科技大学三峡大学天津市泰达医院中南大学湘雅三医院更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划The Royal Society更多>>
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Role of GLCCI1 in inhibiting PI3K-induced NLRP3 inflammasome activation in asthma
《Chinese Medical Journal Pulmonary and Critical Care Medicine》2024年第4期279-288,共10页Yingyu Zhang Yuanyuan Jiang Daimo Zhang Xinyue Hu Shuanglinzi Deng Xiaozhao Li Juntao Feng 
supported by National Natural Science Foundation of China(Nos.82270033;81873407);Natural Science Foundation of Hunan province(No.2022JJ30924).
Background:Glucocorticoid-induced transcript 1(GLCCI1)has been reported to be associated with the efficiency of inhaled glucocorticoids in patients with asthma.This study aimed to investigate the role of GLCCI1 in the...
关键词：ASTHMA NLRP3 inflammasome Glucocorticoid-induced transcript 1(GLCCI1) PI3K signaling pathway Macrophage 
Retraction:Knockdown of Long Noncoding RNA(lncRNA)Metastasis-Associated Lung Adenocarcinoma Transcript 1(MALAT1)Inhibits Proliferation,Migration,and Invasion and Promotes Apoptosis by Targeting miR-124 in Retinoblastoma
《Oncology Research》2024年第9期1529-1529,共1页Oncology Research Editorial Office 
Following the publication,concerns have been raised about a number of figures in this article.The western blots in this article were presented with atypical,unusually shaped and possibly anomalous protein bands in man...
关键词：Lung raised shaped 
Colon cancer-associated transcript 1(CCAT1):A potential novel target in cancer therapy
《Chinese Medical Journal》2024年第17期2128-2130,共3页Jinjie Ma Junpeng Pei Xueping Zhang Xiao Bai Siqi Ding Dongqiu Dai 
supported by the grant from the National Natural Science Foundation of China(No.81972322).
To the Editor:Long non-coding RNAs(lncRNAs)are a class of RNA molecules comprising more than 200 nucleotides in length,which possess negligible ability to encode functional proteins.LncRNAs are involved in several cel...
关键词：CCAT1 COLON CANCER 
Single-cell transcriptomic analysis reveals transcript enrichment in oxidative phosphorylation,fluid sheer stress,and inflammatory pathways in obesity-related glomerulopathy
《Genes & Diseases》2024年第4期314-326,共13页Yinyin Chen Yushun Gong Jia Zou Guoli Li Fan Zhang Yiya Yang Yumei Liang Wenni Dai Liyu He Hengcheng Lu 
supported by the Hunan Provincial Natural Science Foundation for Outstanding Youth(China)(No.2022JJ10093,2020JJ2020);the Scientific Research Fund of Hunan Provincial Health Commission(China)(No.B202303056777);the Major Research and Development Program of Hunan Province,China(No.2020SK2116);the Key Program of Hunan Provincial Health Commission(China)(No.202203052969).
Obesity-related glomerulopathy(ORG)is an independent risk factor for chronic kid-ney disease and even progression to end-stage renal disease.Efforts have been undertaken to elucidate the mechanisms underlying the deve...
关键词：Fluid shear stress Inflammation Obesity-related glomerulopathy Oxidative phosphorylation Single-cell RNA seq 
Long noncoding nuclear enriched abundant transcript 1_2 is a promising biomarker for childhood-onset systemic lupus erythematosus
《Pediatric Investigation》2024年第2期101-107,共7页Shipeng Li Xia Wang Xiaozhen Zhao Jianghong Deng Weiying Kuang Junmei Zhang Xiaohua Tan Chao Li Caifeng Li 
National Natural Science Foundation of China,Grant/Award Number:81701604;R&D program of Beijing Municipal Education Commission,Grant/Award Number:202210025037。
Importance:Systemic lupus erythematosus(SLE)is a diffuse connective tissue disease with complex clinical manifestations and prolonged course.The early diagnosis and condition monitoring of SLE are crucial to disease p...
关键词：BIOMARKER Children LncRNA SLE NEAT1 
RNAirport:a deep neural network-based database characterizing representative gene models inplants被引量：1
《Journal of Genetics and Genomics》2024年第6期652-664,共13页Sitao Zhu Shu Yuan Ruixia Niu Yulu Zhou Zhao Wang Guoyong Xu 
supported by grants from the National Key R&D Program of China(2023ZD04073);the Major Project of Hubei Hongshan Laboratory(2022hszd016);the Key Research and Development Program of Hubei Province(2022BFE003);the National Natural Science Foundation of China(32070284)to G.Xu.
A 5'-leader,known initially as the 5'-untranslated region,contains multiple isoforms due to alternative splicing(aS)and alternative transcription start site(aTSS).Therefore,a representative 5'-leader is demanded to ex...
关键词：5'-leader Transcript isoforms RNA regulatory elements UORF Deep learning Synthetic biology Translational control 
Prostate cancer-associated transcript 6(PCAT6)promotes epithelial-mesenchymal transition and stemness and worsens prognosis in patients with colorectal cancer
《Acta Biochimica et Biophysica Sinica》2024年第6期866-878,共13页Xun Sun Yitao Yuan Suyao Li Lu Gan Midie Xu Qingguo Li Mengling Liu Keshu Hu Ke Nan Jiayu Zhang Yu Dong Yufu Lin Xiuping Zhang Pengcong Hou Tianshu Liu 
supported by the grants from the National Natural Science Foundation of China(Nos.82172925,81802370 and 8217111492);Shanghai Natural Science Foundation(No.23ZR1421300);Youth Foundation of Zhongshan Hospital Fudan University(2022ZSQN09);Xiamen Natural Science Foundation Project(3502Z20227111);Fujian Provincial Health Technology Project(2021QNB020).
Approximately 20%of colorectal cancer(CRC)patients are first diagnosed with metastatic colorectal cancer(mCRC)because they develop symptoms at an advanced stage.Despite advancements in treatment,patients with metastat...
关键词：colorectal cancer lncRNA PCAT6 METASTASIS 
Boosting genome editing in plants with single transcript unit surrogate reporter systems被引量：1
《Plant Communications》2024年第6期32-43,共12页Xu Tang Qiurong Ren Xiaodan Yan Rui Zhang Li Liu Qinqin Han Xuelian Zheng Yiping Qi Hongyuan Song Yong Zhang 
supported by the National Key Research and Development Program of China(award no.2023YFD1202900);the National Science Foundation of China(award nos.32270433 and 32101205);the Natural Science Foundation of Sichuan Province(award no.2022NSFSC0143)to Y.Z.and X.T.,the Joint Science and Technology Project between Sichuan Province and Chongqing Municipality(award no.CSTC2021JSCXCYLHX0001)to H.S.and X.T.;the Modern Seed Industry Project of Chongqing Municipal Science and Technology Bureau(award no.CSTB2023TIAD-KPX0025)to H.S.;the National Science Foundation of China(award no.32301248)to Q.R.;the National Science Foundation of China(award no.32072045)to X.Z.;supported by the NSF Plant Genome Research Program(award nos.IOS-2029889 and IOS-2132693)to Y.Q.
CRISPR-Cas-based genome editing holds immense promise for advancing plant genomics and crop enhancement.However,the challenge of low editing activity complicates the identification of editing events.In this study,we i...
关键词：CRISPR-Cas9 single transcript unit STU surrogate reporter SR single strand annealing SSA cyto-sine base editing adenine base editing 
Tanshinone ⅡA improves Alzheimer’s disease via RNA nuclearenriched abundant transcript 1/microRNA-291a-3p/member RAS oncogene family Rab22a axis被引量：2
《World Journal of Psychiatry》2024年第4期563-581,共19页Long-Xiu Yang Man Luo Sheng-Yu Li 
Supported by 2020 Guangxi Zhuang Autonomous Region Health Care Commission Self-Financing Research Projects,No.Z20200096;2023 Guangxi University Young and Middle-Aged Teachers’Basic Research Ability Improvement Project,No.2023KY0091;National Natural Science Foundation of China,No.82260241;the Natural Science Foundation of Guangxi Province,No.2015GXNSFAA139171 and No.2020GXNSFAA259053.
BACKGROUND Alzheimer’s disease(AD)is a neurodegenerative condition characterized by oxidative stress and neuroinflammation.Tanshinone ⅡA(Tan-ⅡA),a bioactive compound isolated from Salvia miltiorrhiza plants,has sho...
关键词：TanshinoneⅡA Alzheimer’s disease Nuclear-enriched abundant transcript 1 Member of RAS oncogene family Rab22a Reactive oxygen species 
Transcript selection for the genetic diagnosis of KIF12-associated progressive familial intrahepatic cholestasis
《Gastroenterology Report》2024年第1期787-789,共3页Ye Cheng Yi-Qiong Zhang Bing-Xuan Wei Lian Chen Qing-He Xing Jian-She Wang 
supported by the National Key Research and Development Program from the Ministry of Science and Technology of the People’s Republic of China[2021YFC2700800];the Shanghai Municipal Commission of Science and Technology Research Project[19JC1411002].
Introduction Cholestatic jaundice in infancy occurs in-1 in 2,500 term infants and 25%of cases are genetically determined[1].An accurate diagnosis is crucial for clinicians to provide timely and personalized managemen...
关键词：DIAGNOSIS FAMILIAL CASES 
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