Prostate cancer-associated transcript 6(PCAT6)promotes epithelial-mesenchymal transition and stemness and worsens prognosis in patients with colorectal cancer  

作　　者：Xun Sun Yitao Yuan Suyao Li Lu Gan Midie Xu Qingguo Li Mengling Liu Keshu Hu Ke Nan Jiayu Zhang Yu Dong Yufu Lin Xiuping Zhang Pengcong Hou Tianshu Liu 

机构地区：[1]Department of Medical Oncology,Zhongshan Hospital,Fudan University,Shanghai 200032,China [2]Cancer Center,Zhongshan Hospital,Fudan University,Shanghai 200032,China [3]Shanghai Institute of Precision Medicine,Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200032,China [4]Department of Anesthesiology,Zhongshan Hospital,Fudan University,Shanghai 200032,China [5]Fudan Zhangjiang Institute,Shanghai 201203,China [6]Department of Pathology and Tissue Bank,Fudan University Shanghai Cancer Center,Shanghai,200032,China [7]Department of Colorectal Surgery,Fudan University Shanghai Cancer Center,Shanghai,200032,China [8]Department of Oncology,Shanghai Medical College,Fudan University,Shanghai 200032,China [9]Department of Oncology,Zhongshan Hospital (Xiamen),Fudan University,Xiamen 361015,China [10]Xiamen Clinical Research Center for Cancer Therapy,Xiamen Branch,Zhongshan Hospital,Fudan University,Xiamen 361015,China

出　　处：《Acta Biochimica et Biophysica Sinica》2024年第6期866-878,共13页生物化学与生物物理学报（英文版）

基　　金：supported by the grants from the National Natural Science Foundation of China(Nos.82172925,81802370 and 8217111492);Shanghai Natural Science Foundation(No.23ZR1421300);Youth Foundation of Zhongshan Hospital Fudan University(2022ZSQN09);Xiamen Natural Science Foundation Project(3502Z20227111);Fujian Provincial Health Technology Project(2021QNB020).

摘　　要：Approximately 20%of colorectal cancer(CRC)patients are first diagnosed with metastatic colorectal cancer(mCRC)because they develop symptoms at an advanced stage.Despite advancements in treatment,patients with metastatic disease still experience inferior survival rates.Our objective is to investigate the association between long noncoding RNAs(lncRNAs)and prognosis and to explore their role in mCRC.In this study,we find that elevated expression of PCAT6 is independently linked to unfavourable survival outcomes in The Cancer Genome Atlas(TCGA)data,and this finding is further confirmed in CRC samples obtained from Fudan University Shanghai Cancer Center.Cell lines and xenograft mouse models are used to examine the impact of PCAT6 on tumor metastasis.Knockdown of PCAT6 is observed to impede the metastatic phenotype of CRC,as evidenced by functional assays,demonstrating the suppression of epithelial-mesenchymal transition(EMT)and stemness.Our findings show the significance of PCAT6 in mCRC and its potential use as a prognostic biomarker.

关 键 词：colorectal cancer lncRNA PCAT6 METASTASIS 

分 类 号：R737.25[医药卫生—肿瘤]