UORF

作品数:8被引量:13H指数:2
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相关领域:生物学农业科学更多>>
相关作者:张弩边腾飞周萍金勇丰赵建国更多>>
相关机构:中山大学附属第一医院中国医科大学武汉大学上海交通大学更多>>
相关期刊:《American Journal of Molecular Biology》《农业生物技术学报》《生物技术通报》《Science China(Life Sciences)》更多>>
相关基金:国家自然科学基金辽宁省科学技术计划项目教育部留学回国人员科研启动基金广东省科技计划工业攻关项目更多>>
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Adjusting the amylose content of semi-glutinous japonica rice by genome editing of uORF6 in the Wx gene
《The Crop Journal》2024年第6期1806-1811,共6页Kai Lu Yadong Zhang Lei He Cheng Li Wenhua Liang Tao Chen Qingyong Zhao Zhen Zhu Ling Zhao Chunfang Zhao Xiaodong Wei Shu Yao Lihui Zhou Qiaoquan Liu Cailin Wang 
supported by the National Key Research and Development Program of China (2023YFD1200900);the Zhongshan Biological Breeding Laboratory (BM2022008-02/03);the Key Research and Development Projects of Jiangsu Province (BE2023355);the“JBGS”Project of Seed Industry Revitalization in Jiangsu Province (JBGS (2021)041).
Amylose content,the key determinant of rice eating and cooking quality,is regulated primarily by the Waxy(Wx)gene.We adjusted the amylose content and transparency of semi-glutinous japonica rice carrying the Wxmp alle...
关键词:Amylose content Eating and cooking quality Semi-glutinous japonica rice WX UORF 
Engineering disease-resistant plants with alternative translation efficiency by switching uORF types through CRISPR被引量:1
《Science China(Life Sciences)》2024年第8期1715-1726,共12页Jingjing Tian Zhijuan Tang Ruixia Niu Yulu Zhou Dan Yang Dan Chen Ming Luo Rui Mou Meng Yuan Guoyong Xu 
supported by the National Key Research and Development Program of China(2023ZD04073);the Major Project of Hubei Hongshan Laboratory(2022hszd016);the National Natural Science Foundation of China(32070284,32172421);the Key Research and Development Program of Hubei Province(2022BFE003);the Fundamental Research Funds for the Central Universities(2662023PY006).
Engineering disease-resistant plants can be a powerful solution to the issue of food security.However,it requires addressing two fundamental questions:what genes to express and how to control their expressions.To find...
关键词:disease-resistant plants broad-spectrum disease resistance UORF uORF types uORF variants CRISPR 
RNAirport:a deep neural network-based database characterizing representative gene models inplants被引量:1
《Journal of Genetics and Genomics》2024年第6期652-664,共13页Sitao Zhu Shu Yuan Ruixia Niu Yulu Zhou Zhao Wang Guoyong Xu 
supported by grants from the National Key R&D Program of China(2023ZD04073);the Major Project of Hubei Hongshan Laboratory(2022hszd016);the Key Research and Development Program of Hubei Province(2022BFE003);the National Natural Science Foundation of China(32070284)to G.Xu.
A 5'-leader,known initially as the 5'-untranslated region,contains multiple isoforms due to alternative splicing(aS)and alternative transcription start site(aTSS).Therefore,a representative 5'-leader is demanded to ex...
关键词:5'-leader Transcript isoforms RNA regulatory elements UORF Deep learning Synthetic biology Translational control 
Translation machinery: the basis of translational control被引量:2
《Journal of Genetics and Genomics》2024年第4期367-378,共12页Shu Yuan Guilong Zhou Guoyong Xu 
supported by grants from the National Natural Science Foundation of China(32070284);the Major Project of Hubei Hongshan Laboratory(2022hszd016);the Key Research and Development Program of Hubei Province(2022BFE003)to G.Xu.We apologize to colleagues whose excellent work was not cited in this review due to the space limit.
Messenger RNA(mRNA)translation consists of initiation,elongation,termination,and ribosome recycling,carried out by the translation machinery,primarily including tRNAs,ribosomes,and translation factors(TrFs).Translatio...
关键词:Translational control RIBOSOME TRNA Translation machinery UORF Phase separation Immune response 
植物基因上游开放阅读框的研究进展被引量:1
《生物技术通报》2023年第4期157-165,共9页薛皦 朱庆锋 冯彦钊 陈沛 刘文华 张爱霞 刘勤坚 张琪 于洋 
广东省自然科学基金项目(2021A1515110411);广东省农业科学院科技人才引进专项资金项目(R2021YJ-QG005);广东省粤穗联合基金重点项目(2019B1515120061);广东省重点领域研发计划项目(2020B020220008);广东省科技计划项目(2020B121201013)。
上游开放阅读框(upstream open reading frame, uORF)是一类能够精确控制蛋白质翻译的mRNA元件,位于mRNA的5'端前导区,主要通过抑制翻译起始来调节下游主体开放阅读框(main open reading frame, mORF)的翻译。目前对植物uORF的预测和鉴...
关键词:UORF 翻译调控 核糖体 生长发育 作物育种 
微生物小开放阅读框:小蛋白及翻译调控研究进展
《微生物学报》2023年第1期1-14,共14页杨婕 张安琪 冯家勋 赵帅 赵心清 
国家自然科学基金地区联合基金重点项目(U21A20178);国家重点研发计划(2021YFC2101302)。
小开放阅读框(small open reading frame,sORF)广泛存在于不同生物基因组中,由于其序列短,以及编码的产物小蛋白(small protein,或称微蛋白;microprotein或迷你蛋白miniprotein)检测困难等原因,小开放阅读框长期未得到充分注释和研究。...
关键词:小开放阅读框(sORF) 小蛋白 上游开放阅读框(uORF) 翻译调控 微生物基因组 
Higher Concentrations of Glucose or Insulin Increase the Risk of Various Types of Cancer in Obesity or Type 2 Diabetes by Decreasing the Expression of p27Kip1, a Cell Cycle Repressor Protein被引量:1
《American Journal of Molecular Biology》2020年第1期1-11,共11页Isao Eto 
Research Aims: Obesity and type 2 diabetes are known to be associated with increased risk of various types of cancer. However, the molecular biological mechanism of how the risk of cancer is increased in obesity or ty...
关键词:OBESITY Type 2 Diabetes CANCER P27KIP1 MRNA Translation Initiation 5’-Untranslated Region (5’UTR) 5’-End Cap of P27KIP1 MRNA Upstream Open Reading Frame (uORF) Internal RIBOSOME Entry Site (IRES) 
高等植物基因上游可译框架(uORF)的分析被引量:7
《农业生物技术学报》2004年第5期493-499,共7页金勇丰 边腾飞 周萍 
留学回国基金项目(No.G50373)资助
真核生物 mRNA 5′非编码区上游可译框(uORF)在基因翻译水平上的调控具有重要作用。对植物2200多个 cD-NA 序列5′非编码区的 uATG 和 uORF 进行统计分析,结果表明,含 uATG 的基因高达18%,这一比例比估计的10%要高得多,其中含单个 uATG...
关键词:基因 RNA 非编码区 序列 列缺 翻译水平 氨基酸 起始密码子 高等植物 真核生物 
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