Mass acquisition of human periodontal ligament stem cells  

作　　者：Hidefumi Maeda 

机构地区：[1]Department of Endodontology and Operative Dentistry,Division of Oral Rehabilitation,Faculty of Dental Science,Kyushu University,3-1-1 Maidashi,Fukuoka 8128582,Japan

出　　处：《World Journal of Stem Cells》2020年第9期1023-1031,共9页世界干细胞杂志（英文版）（电子版）

基　　金：Supported by Japan Society for the Promotion of Science,No.JP17H01598.

摘　　要：The periodontal ligament(PDL)is an essential fibrous tissue for tooth retention in the alveolar bone socket.PDL tissue further functions to cushion occlusal force,maintain alveolar bone height,allow orthodontic tooth movement,and connect tooth roots with bone.Severe periodontitis,deep caries,and trauma cause irreversible damage to this tissue,eventually leading to tooth loss through the destruction of tooth retention.Many patients suffer from these diseases worldwide,and its prevalence increases with age.To address this issue,regenerative medicine for damaged PDL tissue as well as the surrounding tissues has been extensively investigated regarding the potential and effectiveness of stem cells,scaffolds,and cytokines as well as their combined applications.In particular,PDL stem cells(PDLSCs)have been well studied.In this review,I discuss comprehensive studies on PDLSCs performed in vivo and contemporary reports focusing on the acquisition of large numbers of PDLSCs for therapeutic applications because of the very small number of PDLSCs available in vivo.

关 键 词：Induced pluripotent stem cells Mesoderm specific transcript Periodontal ligament stem cells Periodontal tissue Regenerative medicine Semaphorin 3A 

分 类 号：R781.42[医药卫生—口腔医学]