Kindler syndrome protein Kindlin-1 is mainly expressed in adult tissues originating from ectoderm/endoderm  

作　　者：ZHAN Jun YANG Mei ZHANG Jing GUO YongQing LIU Wei ZHANG HongQuan 

机构地区：[1]Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center [2]Laboratory of Molecular Cell Biology and Tumor Biology, Department of Anatomy, Histology and Embryology, Peking University Health Science Center [3]Department of Thoracic Surgery, Sino-Japan Friendship Hospital [4]Department of Immunology, Third Military Medical University

出　　处：《Science China(Life Sciences)》2015年第5期432-441,共10页中国科学（生命科学英文版）

基　　金：supported by the National Natural Science Foundation of China(81301802,81230051,30830048,31170711);Grant of Ministry of Science and Technology of China(2013CB910501,2010CB912203,2010CB529402);Program for Introducing Talents of Discipline to Universities(111 Project)of Ministry of Education;Beijing Natural Science Foundation(7120002);Peking University grants(BMU20120314,BMU20130364,BMU20130373);a Leading Academic Discipline Project of Beijing Education Bureau

摘　　要：Mutations of integrin-interacting protein Kindlin-1 cause Kindler syndrome and deregulation of Kindlin-1 is implicated in human cancers. The Kindlin-1-related diseases are confined in limited tissue types. However, Kindlin-1 tissue distribution and the dogma that governs Kindlin-1 expression in normal human body are elusive. This study examined Kindlin-1 expression in normal human adult organs, human and mouse embryonic organs by immunohistochemical analyses. We identified a general principle that the level of Kindlin-1 expression in tissues is tightly correlated with the corresponding germ layers from which these tissues originate. We compared the expression of Kindlin-1 with Kindlin-2 and found that Kindlin-1 is highly expressed in epithelial tissues derived from ectoderm and endoderm, whereas Kindlin-2 is mainly expressed in mesoderm-derived tissues. Likewise, Kindlin-1 was also found highly expressed in endoderm/ectoderm-derived tissues in human and mouse embryos. Our findings indicate that Kindlin-1 may play an importance role in the development of endoderm/ectoderm related tissues.Mutations of integrin-interacting protein Kindlin-1 cause Kindler syndrome and deregulation of Kindlin-1 is implicated in human cancers. The Kindlin-1-related diseases are confined in limited tissue types. However, Kindlin-1 tissue distribution and the dogma that governs Kindlin-1 expression in normal human body are elusive. This study examined Kindlin-1 expression in normal human adult organs, human and mouse embryonic organs by immunohistochemical analyses. We identified a general principle that the level of Kindlin-1 expression in tissues is tightly correlated with the corresponding germ layers from which these tissues originate. We compared the expression of Kindlin-1 with Kindlin-2 and found that Kindlin-1 is highly expressed in epithelial tissues derived from ectoderm and endoderm, whereas Kindlin-2 is mainly expressed in mesoderm-derived tissues. Likewise, Kindlin-1 was also found highly expressed in endoderm/ectoderm-derived tissues in human and mouse embryos. Our findings indicate that Kindlin-1 may play an importance role in the development of endoderm/ectoderm related tissues.

关 键 词：Kindlin- 1 epithelial tissue ECTODERM ENDODERM embryo 

分 类 号：R758.5[医药卫生—皮肤病学与性病学]