Liver development in zebrafish (Danio rerio)  

作　　者：Ting Tao Jinrong Peng 

机构地区：[1]College of Animal Science, Zhejiang University, Hangzhou 310029, China

出　　处：《Journal of Genetics and Genomics》2009年第6期325-334,共10页遗传学报（英文版）

基　　金：supported by the National Natural Science Foundation of China (No. 30825025)

摘　　要：Liver is one of the largest internal organs in the body and its importance for metabolism, detoxification and homeostasis has been well established. In this review, we summarized recent progresses in studying liver initiation and development during embryogenesis using zebrafish as a model system. We mainly focused on topics related to the specification of hepatoblasts from endoderm, the formation and growth of liver bud, the differentiation of hepatocytes and bile duct cells from hepatoblasts, and finally the role of mesodermal signals in controlling liver development in zebrafish.Liver is one of the largest internal organs in the body and its importance for metabolism, detoxification and homeostasis has been well established. In this review, we summarized recent progresses in studying liver initiation and development during embryogenesis using zebrafish as a model system. We mainly focused on topics related to the specification of hepatoblasts from endoderm, the formation and growth of liver bud, the differentiation of hepatocytes and bile duct cells from hepatoblasts, and finally the role of mesodermal signals in controlling liver development in zebrafish.

关 键 词：ZEBRAFISH model organism liver development ENDODERM 

分 类 号：X503.225[环境科学与工程—环境工程]