the Russian Science Foundation(Grant No.20-75-10132).
Background:Immune checkpoint ligand-receptor interactions appear to be associated with multiple myeloma(MM)progression.Simultaneously,previous studies showed the possibility of PD-1 and TIM-3 expression on T cells upo...
supported by the Natural Science Foundation of China(32330034,31830027,31821003,82271754 and 82071737);the National Key Research&Developmental Program of China(2022YFF0710602);the Excellent Research and Innovation Team in Anhui Province’s Universities(2023AH010085);the China Postdoctoral Science Foundation(2020M670296 and 2021T140372).
Eomesodermin(Eomes)is a critical factor in the development of natural killer(NK)cells,but its precise role in temporal and spatial coordination during this process remains unclear.Our study revealed that Eomes plays d...
Background: Aspergillosis infection is common in the patients with insufficient immunity. The role of mammalian target of rapamycin (roTOR), T-box expressed in T-cells (T-bet), and eomesodermin (EOMES) in media...
Acknowledgements We thank Drs Alex Schier and Susan Mango (Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA) for discussion and suggestions, Dr David Kimelman (Department of Biochemistry, University of Washington, Seattle, WA, USA) for myc-eomesa construct, and members of the Meng lab for discussion and technical assistance. This work was financially supported by grants from the Major Science Research Programs of China (2011CB943800) and the National Natural Science Foundation of China (31221064).
Development of animal embryos before zygotic genome activation at the mid blastula transition (MBT) is essentially supported by eggderived maternal products. Nodal proteins are crucial signals for mesoderm and endod...