funded by grants from the National Key Research and Development Program(2019YFA0110001 and 2022YFC2702200);the National Natural Science Foundation of China(82288102,82125013,82201838,and 82101677);the Young Elite Scientists Sponsorship Program by China Association for Science and Technology(YESS20200398)。
Human fetuses exhibit notable sex differences in growth rate and response to the intrauterine environment,yet their origins and underlying mechanisms remain uncertain.Here,we conduct a detailed investigation of sex di...
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License,which permits use,sharing,adaptation,distribution and reproduction in any medium or format,as long as you give approp...
The study was supported by the National Key R&D Program of China(2018YFC1004500,2017YFC1001401,2019YFA0508900);the National Natural Science Foundation of China(31930033,31590832,31988101,31725018).
The pluripotency of mammalian early and late epiblast could be recapitulated by naïve embryonic stem cells(ESCs)and primed epiblast stem cells(EpiSCs),respectively.However,these two states of pluripotency may not be s...
With the support by the National Natural Science Foundation of China,the research team led by Prof.Li TianQing(李天晴)at the Yunnan Key Laboratory of Primate Biomedical Research,Institute of Primate Translational Medi...
National Key R&D Program of China(2018YFC1004500 ond 2017YFC1001401);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16020700);‘light of West China’Program of Chinese Academy of Sciences.
The fertilized egg undergoes several cleavage divisions to form the blastocyst in the oviduct.The blastocyst then is transferred to the uterus to initiate implantation,and trophectoderm-derived cells interact with the...
the grants from the National Natural Science Foundation of China (No.81571442);the Major State Basic Research Development Program of China (No.2011CB966301).
Epiboly spreads and thins the blastoderm over the yolk cell during zebrafish gastrulation.Despite of its fundamental function,little is known about the molecular mechanisms that control this coordinated cell movement....
supported by the “Strategic Priority Research Program” of the Chinese Academy of Sciences (XDA01010201);National Key Basic Research and Development Program of China (2014CB964804, 2015CB964500);National Natural Science Foundation of China (31430058, 31571513, 31630043, 91519314)
The diverse morphologies among vertebrate species stems from the evolution of a basic body plan that is constituted by a spatially organized ensemble of tissue lineage progenitors. At gastrulation, this body plan is e...
supported by grants from the National Basic Research Program of China(2010CB126300);the National High Technology Research and Development Program of China(2012AA092201-3);Ministry of Agriculture of China within the special Fund for Agro-scientific Research in the Public Interest(200903045);the National Natural Science Foundation of China(30971414)
Apolipoprotein C1 (Apocl) is associated with lipoprotein metabolism, but its physiological role during embryogenesis is largely unknown. We reveal a new function of Apoclb, a transcript isoform of Apocl, in epiboly ...
supported by the grants from the Major Science Programs of China(Nos.2011CBA01101 and 2011CB943904);the National Natural Science Foundation of China(Nos.30971656 and 90919011)
Nodal, a member of the transforming growth factor β (TGF-β) superfamily, has been shown to play a role in mesendoderm induction and gastrulation movements. The activity of Nodal signaling can be modulated by micro...
Repressor element 1-silencing transcription factor (REST) was recognized as a transcription suppressor regulating nervous system differentiation. However, the role of REST during early development has not been clari...