云南高校图书馆联盟文献共享服务平台- MORPHOLINO

MORPHOLINO: 作品数：27被引量：38H指数：4; 导出分析报告; 相关领域：生物学更多>>; 相关作者：夏兴华季一飞杜晓霞夏孝强曹雷更多>>; 相关机构：湖南师范大学南京大学南方医科大学华中科技大学更多>>; 相关期刊：《Acta Biochimica et Biophysica Sinica》《湖南师范大学自然科学学报》《口腔医学》《基因组学与应用生物学》更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家教育部博士点基金江苏省自然科学基金更多>>

Beyond ribosomal function:RPS6 deficiency suppresses cholangiocarcinoma cell growth by disrupting alternative splicing: 《Acta Pharmaceutica Sinica B》2024年第9期3931-3948,共18页Wenkang Fu Yanyan Lin Mingzhen Bai Jia Yao Chongfei Huang Long Gao Ningning Mi Haidong Ma Liang Tian Ping Yue Yong Zhang Jinduo zhang Yanxian Ren Liyun Ding Lunzhi Dai Joseph WLeung Jinqiu Yuan Wenhua Zhang Wenbo Meng; the National Key Research and Development Program of China(2022YFC2407405);National Natural Science Foundation of China(82060551,32160230);Natural Science foundation of Gansu Province(22JR5RA891,China);Gansu Provincial Health Industry Research Program(GSWSQH2021-001,China);Science and Technology Bureau Talent Innovation Program of Chengguan District(2019RCCX0038,China).; Cholangiocarcinoma(CCA)is a bile duct malignancy with a dismal prognosis.This study systematically investigated the role of the ribosomal protein S6(RPS6)gene,which is dependent in CCA.We found that RPS6 upregulation ...; 关键词：CHOLANGIOCARCINOMA Ribosomal protein S6 Alternative splicing p53 Minichromosome maintenance complex component 7 Vivo morpholino Patient-derived organoids

Morpholino studies shed light on the signaling pathways regulating axon regeneration in lampreys: 《Neural Regeneration Research》2022年第7期1475-1477,共3页Daniel Sobrido-Cameán Antón Barreiro-Iglesias; Lampreys are one of the most ancient extant vertebrates and they have become an animal model of interest for the study of spontaneous axon regeneration after a traumatic central nervous system injury.Contrary to most ...; 关键词：TRAUMATIC regeneration INJURY

lncRNA ihha-as在斑马鱼早期胚胎发育中的功能研究: 《湖南师范大学自然科学学报》2021年第6期85-91,共7页欧阳奇李小灯远长悦李婧琳韩梅胡翔; 长沙市自然科学基金(kq2007013);省部共建淡水鱼类发育生物学国家重点实验室开放基金(2020KF003);湖南师范大学大学生创新创业基金(2021118)。; 为了探究lncRNA ihha-as在斑马鱼早期胚胎和心脏发育中的作用,利用NCBI blast和UCSC Genome Browser对ihha-as进行序列保守性分析,通过半定量PCR和qPCR及原位杂交实验确定ihha-as在斑马鱼中的时空表达,运用ihha-as-morpholino敲低和ihha...; 关键词：lncRNA ihha-as 斑马鱼心脏发育 MORPHOLINO

Inhibition of GABAA-ρreceptors induces retina regeneration in zebrafish被引量：3: 《Neural Regeneration Research》2021年第2期367-374,共8页Matthew R.Kent Nergis Kara James G.Patton; grants from the NIH R01EY024354-S1 and UO1 EY027265 to JGP;and T32 EY021453;additional support from the Stevenson family and Gisela Mosig endowments to Vanderbilt University。; A potential treatment for retinal diseases is to induce an endogenous Müller glia(MG)-derived regenerative response to replace damaged neurons.In contrast to mammalian MG,zebrafish MG are capable of mediating spontan...; 关键词：gamma aminobutyric acid MORPHOLINO Müller glia NEUROTRANSMITTER REGENERATION RETINA stem cells ZEBRAFISH

基因编辑技术在斑马鱼中的应用及研究进展被引量：1: 《基因组学与应用生物学》2020年第2期591-598,共8页雷立芳蔡英桂王宏波吴秀山叶湘漓; 国家自然科学基金(81971086,81270291);国家留学基金(CSC201708430158,CSC201806375055);湖南省教育厅科学研究重点项目(18A028)共同资助。; 基因编辑技术通过对特定DNA片段的插入、敲除、修饰或替换等,实现对生物体中目标基因的编辑。与早期基因工程技术将遗传物质随机插入宿主基因组中的方式不同的是,基因编辑技术能够定点需要插入的位置,从而实现对生物体基因组特定位点的...; 关键词：基因编辑斑马鱼 MORPHOLINO ZFNs TALEN CRISPR/Cas系统

Prmt7 regulates epiboly and gastrulation ce movements by facilitating syntenin被引量：1: 《Acta Biochimica et Biophysica Sinica》2018年第12期1280-1287,共8页Wuwen Zhang Yunbin Zhang Shifeng Li Zhili Wu Yuanchang Yan Yiping Li; the grants from the National Natural Science Foundation of China (No.81571442);the Major State Basic Research Development Program of China (No.2011CB966301).; Epiboly spreads and thins the blastoderm over the yolk cell during zebrafish gastrulation.Despite of its fundamental function,little is known about the molecular mechanisms that control this coordinated cell movement....; 关键词：EPIBOLY Print7 SYNTENIN MORPHOLINO CYTOSKELETON

The genetic program Of oocytes can be modified in vivo in the zebrafish ovary被引量：1: 《Journal of Molecular Cell Biology》2018年第6期479-493,共15页Xiaotong Wu Weimin Shen Bingjie Zhang Anming Meng; the National Natural Science Foundation of China (31330052 and 31590832).; Oocytes,the irreplaceable gametes for generating a new organism,are matured in the ovary of living female animals.It is unknown whether any genetic manipulations can be applied to immature oocytes inside the living ov...; 关键词：OOCYTES MICROINJECTION gene editing TRANSGENESIS MORPHOLINO ZEBRAFISH

Kruppel样因子6对肝癌HepG2细胞的作用及其缺失对斑马鱼肝脏发育的影响被引量：3: 《中国比较医学杂志》2017年第5期42-50,共9页陈浩杨振国伍水龙邬永富冯瑜菲高晓霞包仕廷张晶晶; 广东省科技计划项目(2013B060300021);广东省"培养高层次人才特殊支持计划"专项基金(粤人才办[2015]8号);广东省高等学校优秀青年教师培养计划(YQ2015081);广东医科大学科研基金(XK1418); 目的探讨Kruppel样因子6(KLF6)低表达对肝癌细胞凋亡及迁移能力的影响,并以斑马鱼作为动物模型,研究klf6基因沉默对肝脏发育的作用。方法构建敲除KLF6基因质粒,转染肝癌细胞(HepG2)及正常人肝细胞(L-02),通过免疫印迹(WB)、凋亡及细胞...; 关键词：KLF6基因 HEPG2细胞斑马鱼 MORPHOLINO

RhoA as a target to promote neuronal survival and axon regeneration被引量：4: 《Neural Regeneration Research》2017年第4期525-528,共4页Jianli Hu Michael E. Seizer; supported by R01-NS092876(NIH,MES,PI);SHC-85400(Shriners Research Foundation,MES,PI);SHC-85220(Shriners Research Foundation,MES,PI);SHC-84293(Shriners Research Foundation,JH,PI); Paralysis following spinal cord injury （SCI） is due to failure of axonal regeneration. It is believed that the capacities of neurons to regrow their axons are due partly to their intrinsic characteristics, which in ...; 关键词：RHOA spinal cord injury neuronal survival apoptosis axon regeneration MORPHOLINO C3 transferase

Schiff base aluminum catalysts containing morpholinomethyl groups in the ring opening polymerization of rac-lactide: 《Science China Chemistry》2015年第11期1741-1747,共7页Zhijie Guo Ranlong Duan Mingxiao Deng Xuan Pang Chenyang Hu Xuesi Chen; supported by the National Natural Science Foundation of China(51173183,51233004,51390484,51321062,51473029); A series of Schiff base aluminum(III) complexes bearing morpholinomethyl substituents were synthesized. Comprehensive investigations on their stereoselective and kinetic features in the ring opening polymerization of ...; 关键词：POLYLACTIDE morpholinomethyl ring opening polymerization

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