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Transient chemical-mediated epigenetic modulation confers unrestricted lineage potential on human primed pluripotent stem cells: 《Science China(Life Sciences)》2025年第4期1084-1101,共18页Shi Chen Yuanyuan He Lejun Lv Bei Liu Cheng Li Hongkui Deng Jun Xu; supported by the National Key Research and Development Program of China(2021YFA1100300);the National Natural Science Foundation of China(32288102,32370843 and 32025006)Part of the data analysis was performed on the High Performance Computing Platform of the Center for Life Sciences,Peking University。; Human primed pluripotent stem cells are capable of generating all the embryonic lineages.However,their extraembryonic trophectoderm potentials are limited.It remains unclear how to expand their developmental potential...; 关键词：trophectoderm lineages human primed pluripotent stem cells epigenetic regulation small molecules

Sex differences in human pre-gastrulation embryos: 《Science China(Life Sciences)》2025年第2期397-415,共19页Yongjie Lu Meng Qin Xintong Qi Ming Yang Fan Zhai Jiaqi Zhang Zhiqiang Yan Liying Yan Jie Qiao Peng Yuan; funded by grants from the National Key Research and Development Program(2019YFA0110001 and 2022YFC2702200);the National Natural Science Foundation of China(82288102,82125013,82201838,and 82101677);the Young Elite Scientists Sponsorship Program by China Association for Science and Technology(YESS20200398)。; Human fetuses exhibit notable sex differences in growth rate and response to the intrauterine environment,yet their origins and underlying mechanisms remain uncertain.Here,we conduct a detailed investigation of sex di...; 关键词：human embryo sex difference TROPHECTODERM primitive endoderm EPIBLAST

Bilineage embryo-like structure from EPS cells can produce live mice with tetraploid trophectoderm被引量：2: 《Protein & Cell》2023年第4期262-278,共17页Kuisheng Liu Xiaocui Xu Dandan Bai Yanhe Li Yalin Zhang Yanping Jia Mingyue Guo Xiaoxiao Han Yingdong Liu Yifan Sheng Xiaochen Kou Yanhong Zhao jiqing Yin Sheng Liu jiayu Chen Hong Wang Yixuan Wang Wenqiang Liu Shaorong Gao; supported by the National Key R&D Program of China(Nos.2020YFA0112500 and 2021YFA1102900);the National Natural Science Foundation of China(Nos.31721003,81630035,82022027,31871448,32000418 and 31820103009);supported by the key project of the Science and Technology of Shanghai Municipality(Nos.19JC1415300 and 21JC1405500);the Shanghai municipal medical and health discipline construction projects(No.2017ZZ02015);the China Postdoctoral Science Foundation 2021M692437 and the Fundamental Research Funds for the Central Universities.; Self-organized blastoids from extended pluripotent stem(EPs)cells possess enormous potential for investigating postimplantation embryo development and related diseases.However,the limited ability of postimplantation d...; 关键词：EPS cells blastoid primitive endoderm(PrE) trophectoderm(TE) Gata6

Zearalenone induces apoptosis and autophagy by regulating endoplasmic reticulum stress signalling in porcine trophectoderm cells被引量：5: 《Animal Nutrition》2023年第1期186-199,共14页Jun Bai Jun Li Ning Liu Hai Jia Xuemeng Si Yusong Zhou Zhian Zhai Ying Yang Fazheng Ren Zhenlong Wu; This work was supported by grants from the National Natural Science Foundation of China(No.31625025).; Zearalenone(ZEA),a mycotoxin produced mainly by fungi belonging to Fusarium species in foods and feeds,causes a serious hazard to humans and animals.Numerous studies have revealed that ingesting ZEA can disrupt the re...; 关键词：ZEARALENONE Porcine trophectoderm APOPTOSIS Endoplasmic reticulum stress AUTOPHAGY

Chromatin remodeler INO80 mediates trophectoderm permeability barrier to modulate morula-to-blastocyst transition被引量：2: 《Zoological Research》2021年第5期562-573,共12页Zu-Bing Cao Di Gao Hui-Qun Yin Hui Li Teng-Teng Xu Meng-Ya Zhang Xin Wang Qiu-Chen Liu Ye-Lian Yan Yang-Yang Ma Tong Yu Yun-Sheng Li Yun-Hai Zhang; supported by the Anhui Provincial Natural Science Foundation(1908085MC97,2008085MC85);National Natural Science Foundation of China(31802059,31902226);Hefei Innovation and Entrepreneurship Support Plan for Returnee Scholar(03082009);Anhui Provincial Innovation and Entrepreneurship Support Plan for Returnee Scholar(2020LCX015)。; Inositol requiring mutant 80(INO80)is a chromatin remodeler that regulates pluripotency maintenance of embryonic stem cells and reprogramming of somatic cells into pluripotent stem cells.However,the roles and mechanis...; 关键词：INO80 BLASTOCYST TROPHECTODERM Tight junction Permeability

Functional roles of ornithine decarboxylase and arginine decarboxylase during the peri-implantation period of pregnancy in sheep被引量：5: 《Journal of Animal Science and Biotechnology》2018年第2期306-318,共13页Yasser Y.Lenis Gregory A.Johnson Xiaoqiu Wang Wendy W.Tang Kathrin A.Dunlap M.Carey Satterfield Guoyao Wu Thomas R.Hansen Fuller W.Bazer; supported primarily by the Agriculture and Food Research Initiative Competitive Grants(2016-67,015-24,958 to Fuller W.Bazer and 2015-67,015-23,276 to Guoyao Wu)from the United States Department of Agriculture,National Institute of Food and Agriculture;supported by funding from the Sustainability Strategy2013–2014,from CODI University of Antioquia(Ude A),Medellín,Colombia Scholarship“Becas Doctorado Ude A 2014.”; Background: Polyamines stimulate DNA transcription and m RNA translation for protein synthesis in trophectoderm cells, as well as proliferation and migration of cells; therefore, they are essential for development and...; 关键词：AGMATINE ARGININE INTERFERON tau Polyamines TROPHECTODERM cells

Overall Blastocyst Quality, Trophectoderm Grade, and Inner Cell Mass Grade Predict Pregnancy Outcome in Euploid Blastocyst Transfer Cycles被引量：13: 《Chinese Medical Journal》2018年第11期1261-1267,共7页Yan-Yu Zhao Yang Yu Xiao-Wei Zhang; Background： Despite recent advances that have improved the pregnancy success rates that can be achieved via in vitro fertilization （IVF） therapy, it is not yet clear which blastocyst morphological paralneters best...; 关键词：Blastocyst Inner Cell Mass Embryo Transfer Fertilization In vitro Genetic Testing TROPHOBLASTS

Select nutrients and their effects on conceptus development in mammals被引量：2: 《Animal Nutrition》2015年第3期85-95,共11页Fuller W.Bazer Xiaoqiu Wang Greg A.Johnson Guoyao Wu; supported by National Research Initiative Competitive Grants from the Animal Reproduction Program (2008-35203-19120, 2009-35206-05211, 201167015-20067, and 2011-67015-20028);Animal Growth & Nutrient Utilization Program (2008-35206-18764) of the USDA National Institute of Food and Agriculture;Texas A&M Agri Life Research (H-8200); The dialogue between the mammalian conceptus(embryo/fetus and associated membranes) involves signaling for pregnancy recognition and maintenance of pregnancy during the critical peri-implantation period of pregnancy w...; 关键词：Amino acids Secreted phosphoprotein 1 Pregnancy Interferon tau Conceptus development TROPHECTODERM

Influence of Blastocysts Morphological Score on Pregnancy Outcomes in Frozen-thawed Blastocyst Transfers: a Retrospective Study of 741 Cycles被引量：2: 《Journal of Huazhong University of Science and Technology(Medical Sciences)》2014年第5期750-754,共5页刘琳李艳辉丁晓芳耿育红陈春艳高颖; The influence of inner cell mass （ICM） and trophectoderm （TE） score on pregnancy out- comes in frozen-thawed blastocyst transfer cycles was analyzed. A retrospective analysis of 741 cycles of frozen-thawed blastos...; 关键词：thawed embryos transfer vitrification cryopreservation inner cell mass trophectoderm cell pregnancy outcome

Lentivirus Mediated Gene Manipulation in Trophectoderm of Porcine Embryos被引量：1: 《Journal of Northeast Agricultural University(English Edition)》2014年第3期39-45,F0003,共8页Yin Zhi Guo Jia Bou Gerelchimeg Liu Shi-chao Mu Yan-shuang Liu Zhong-hua; Supported by the Scientifi c Research Fund of Heilongjiang Provincial Education Department(11551039); Development of tools that can manipulate gene expression specifically and efficiently in the trophectoderm（TE） lineage would greatly aid understanding the roles of different genetic pathways in TE versus embryonic l...; 关键词：PIG TROPHECTODERM LENTIVIRUS gene manipulation

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