AGMATINE

作品数：36被引量：82H指数：6
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相关领域：医药卫生更多>>
相关作者：李锦李昕秦伯益苏瑞斌何瑞荣更多>>
相关机构：军事医学科学院河北医科大学北京药理毒理研究所华中科技大学更多>>
相关期刊：《中国生物学文摘》《Journal of Animal Science and Biotechnology》《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》更多>>
相关基金：国家自然科学基金北京市自然科学基金国家重点基础研究发展计划更多>>
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Agmatine ameliorates diabetes type 2-induced nephropathy in rats
《Asian Pacific Journal of Tropical Biomedicine》2024年第1期8-16,共9页Fatemah O.Kamel Ohoud Shagroud Mai AAlim A.Sattar Ahmad Gamal S Abd El-Aziz Abdulhadi S.Burzangi Duaa Bakhshwin Maha Jamal Shahid Karim 
The Deanship of Scientific Research at King Abdulaziz University,Jeddah,Saudi Arabia has funded this project,under grant no.(KEP MSc-42-140-1443).
Objective:To assess the nephroprotective potential of agmatine in a rat model of streptozotocin-induced diabetic nephropathy.Methods:A single dose of streptozotocin(40 mg/kg)coupled with a fructose diet induced diabet...
关键词：AGMATINE Type 2 diabetes NEPHROPATHY Oxidative stress NEPHROPROTECTION 
Agmatine as a novel candidate for rapid-onset antidepressant response被引量：1
《World Journal of Psychiatry》2021年第11期981-996,共16页Ana Paula Valverde Anderson Camargo Ana Lúcia S Rodrigues 
Supported by the Conselho Nacional de Desenvolvimento Científico e Tecnológico,No.310113/2017-2;the CNPq Research Productivity Fellowship.
Major depressive disorder(MDD)is a disabling and highly prevalent mood disorder as well as a common cause of suicide.Chronic stress,inflammation,and intestinal dysbiosis have all been shown to play crucial roles in th...
关键词：AGMATINE Fast-acting antidepressants KETAMINE Major depressive disorder Microbiota-gut-brain axis NEUROINFLAMMATION 
Functional roles of ornithine decarboxylase and arginine decarboxylase during the peri-implantation period of pregnancy in sheep被引量：5
《Journal of Animal Science and Biotechnology》2018年第2期306-318,共13页Yasser Y.Lenis Gregory A.Johnson Xiaoqiu Wang Wendy W.Tang Kathrin A.Dunlap M.Carey Satterfield Guoyao Wu Thomas R.Hansen Fuller W.Bazer 
supported primarily by the Agriculture and Food Research Initiative Competitive Grants(2016-67,015-24,958 to Fuller W.Bazer and 2015-67,015-23,276 to Guoyao Wu)from the United States Department of Agriculture,National Institute of Food and Agriculture;supported by funding from the Sustainability Strategy2013–2014,from CODI University of Antioquia(Ude A),Medellín,Colombia Scholarship“Becas Doctorado Ude A 2014.”
Background: Polyamines stimulate DNA transcription and m RNA translation for protein synthesis in trophectoderm cells, as well as proliferation and migration of cells; therefore, they are essential for development and...
关键词：AGMATINE ARGININE INTERFERON tau Polyamines TROPHECTODERM cells 
Agmatine Prevents Adaptation of the Hippocampal Glutamate System in Chronic Morphine-Treated Rats被引量：5
《Neuroscience Bulletin》2016年第6期523-530,共8页Xiao-Fei Wang Tai-Yun Zhao Rui-Bin Su Ning Wu Jin Li 
supported by grants from the National Basic Research Development Program of China (2015CB553504);the National Natural Science Foundation of China (30930040 and 81102426);a Project of the National Science and Technology Support Program of China(2012BAI01B07)
Abstract Chronic exposure to opioids induces adaptation of glutamate neurotransmission, which plays a crucial role in addiction. Our previous studies revealed that agmatine attenuates opioid addiction and prevents the...
关键词：AGMATINE Opioid addiction HippocampusExtracellular glutamate NMDA receptors 
Agmatine induces gastric protection against ischemic injury by reducing vascular permeability in rats被引量：4
《World Journal of Gastroenterology》2012年第18期2188-2196,共9页Abeer A Al Masri Eman El Eter 
Supported by The Deanship of Scientific Research at King Saud University,through research group project,No.RGPVPP-016,entitled "Cardiovascular research Group"
AIM:To investigate the effect of administration of agmatine(AGM) on gastric protection against ischemia reperfusion(I/R) injury.METHODS:Three groups of rats(6/group);sham,gastric I/R injury,and gastric I/R + AGM(100 m...
关键词：Ischemia reperfusion injury Agmatine Wortmannin Vascular permeability Monocyte chemoattractant protein-1 Stomach Vascular endothelial growth factor 
Enzymatic Synthesis of Agmatine by Immobilized Escherichia coli Cells with Arginine Decarboxylase Activity被引量：3
《Chemical Research in Chinese Universities》2011年第6期992-995,共4页ZHANG Wei-guo ZHAO Gen-hai LIU Jun-zhong LIU Qian JIAO Qing-cai 
Supported by the National Technology-Innovation Fund of China(No.02CJ-13-01-16)
A new method for the enzymatic synthesis of agmatine by immobilized Escherichia coli cells with arginine decarboxylase（ADC） activity was established and a series of optimal reaction conditions was set down. The argi...
关键词：Arginine decarboxylase AGMATINE Enzymatic resolution Immobilized cell 
Agmatine reduces nitric oxide synthase expression and peroxynitrite formation in the cerebral cortex in a rat model of transient global cerebral ischemia
《Neural Regeneration Research》2010年第23期1773-1781,共9页Chin Hee Mun Won Taek Lee Kyung Ah Park Jong Eun Lee 
a grant of the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare and Family Affairs, Republic of Korea, No. A080959
Agmatine, an analog of L-arginine, is an endogenous substance synthesized by arginine decarboxylase, which has been shown to possess neuroprotective effects following brain ischemia. Nitric oxide is generated by seque...
关键词：AGMATINE global cerebral ischemia cerebral cortex nitric oxide nitric oxide synthase NEUROPROTECTION 
The regulation of agmatine on MMP expression in the cerebral endothelial cells overexpressed ADC gene
《沈阳药科大学学报》2008年第S1期58-59,共2页YANG Mei-zi1,JIN Yong-jun2,ZHANG Shu-ping1(1.Department of Pharmacology,Bin Zhou Medical University,Yantai 264003,China 2.Department of Endocrinology,Affiliated Hospital of Binzhou Medical University,Binzhou 256603,China) 
Objective In this study we will investigate the effect and possible mechanism of agmatine on MMP expression.Methods We established a transfection of human ADC gene into the murine bEnd.3 cells(bEnd.3-ADC)by the retrov...
关键词：MMP ADC gene ENOS ATF3 
Agmatine promotes expression of brain-derived neurotrophic factor in brainstem facial nucleus in the rat facial nerve injury model被引量：1
《Neural Regeneration Research》2008年第6期618-620,共3页Li Fang Wenlong Luo 
BACKGROUND： Studies have shown that agmatine can reduce inhibition of neuronal regeneration by increasing cyclic adenosine monophosphate and brain-derived neurotrophic factor （BDNF） in the hippocampus of morphine-d...
关键词：AGMATINE facial nerve injury brain-derived neurotrophic factor ELISA 
Agmatine increases proliferation of cultured hippocampal progenitor cells and hippocampal neurogenesis in chronically stressed mice被引量：7
《Acta Pharmacologica Sinica》2006年第11期1395-1400,共6页Yun-feng LI Hong-xia CHEN Ying LIU You-zhi ZHANG Yan-qin LIU Jin LI 
Project supported by grants from the National Natural Science Foundation of China(№30300419);the Natural Science Foundation of Beijing,China(№7042052).
Aim： To explore the mechanism of agmatine＇s antidepressant action. Methods： Male mice were subjected to a variety of unpredictable stressors on a daily basis over a 24-d period. The open-field behaviors of the mice...
关键词：AGMATINE ANTIDEPRESSANT NEUROGENESIS chronic stress hippocampus progenitor cells 
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