Agmatine ameliorates diabetes type 2-induced nephropathy in rats  

作　　者：Fatemah O.Kamel Ohoud Shagroud Mai AAlim A.Sattar Ahmad Gamal S Abd El-Aziz Abdulhadi S.Burzangi Duaa Bakhshwin Maha Jamal Shahid Karim 

机构地区：[1]Department of Clinical Pharmacology,Faculty of Medicine,King Abdulaziz University,Jeddah 21589,Saudi Arabia [2]Department of Anatomy,Faculty of Medicine,King Abdulaziz University,Jeddah 21589,Saudi Arabia

出　　处：《Asian Pacific Journal of Tropical Biomedicine》2024年第1期8-16,共9页亚太热带生物医学杂志（英文版）

基　　金：The Deanship of Scientific Research at King Abdulaziz University,Jeddah,Saudi Arabia has funded this project,under grant no.(KEP MSc-42-140-1443).

摘　　要：Objective:To assess the nephroprotective potential of agmatine in a rat model of streptozotocin-induced diabetic nephropathy.Methods:A single dose of streptozotocin(40 mg/kg)coupled with a fructose diet induced diabetes in Wistar rats.Agmatine(40 and 80 mg/kg)was administered to rats for 12 weeks.The body weight and fasting blood glucose were measured weekly.Insulin level,urine output,total protein,albumin,blood urea nitrogen,creatinine,and cystatin-C were also determined at the end of the experiment.Furthermore,superoxide dismutase,glutathione,interleukin-1β,interleukin-6,and tumor necrosis factor-alpha were evaluated in kidney tissue.Histopathological study was also performed using hematoxylin and eosin staining.Results:Agmatine at both doses significantly increased final body weight,and lowered fasting blood glucose,urine output,insulin,total protein,albumin,blood urea nitrogen,creatinine,and cystatin-C levels compared with the diabetic group(P<0.05).Inflammatory markers and antioxidant effect were significantly improved in agmatine-treated rats.Moreover,the histopathological changes in renal structure were ameliorated by agmatine treatment.Conclusions:Agmatine alleviates diabetic nephropathy by improving renal functions and reducing inflammation and oxidative stress.The molecular mechanisms of its nephroprotective actions need to be investigated in future study.

关 键 词：AGMATINE Type 2 diabetes NEPHROPATHY Oxidative stress NEPHROPROTECTION 

分 类 号：R285.5[医药卫生—中药学]