TROPHOBLASTS

作品数：24被引量：76H指数：4
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相关领域：医药卫生生物学更多>>
相关期刊：《Cellular & Molecular Immunology》《Reproductive and Developmental Medicine》《Stem Cell Discovery》《Chinese Medical Journal》更多>>
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Role of maternal-fetal immune tolerance in the establishment and maintenance of pregnancy
《Chinese Medical Journal》2024年第12期1399-1406,共8页Jingjing Wang Tao Han Xiaoming Zhu 
supported by the Key R&D Projects of Shaanxi Province(No.2021SF-005);the Youth Independent Innovation Project of Tangdu Hospital(No.2023BTDQN020)
Normal pregnancy is a contradictory and complicated physiological process.Although the fetus carries the human leukocyte antigen(HLA)inherited from the paternal line,it does not cause maternal immune rejection.As the ...
关键词：Maternal-fetal interface Immune tolerance TROPHOBLASTS Decidual stromal cells Decidual immune cells 
Focal adhesion kinase signaling is necessary for the hydrogen sulfide-enhanced proliferation,migration,and invasion of HTR8/SVneo human trophoblasts
《Reproductive and Developmental Medicine》2023年第2期75-82,共8页Xian-Li Wang Jing Tang 
special clinical research projects of Shanghai Municipal Health Commission(202140065);Shanghai Rising Stars of Medical Talent Youth Development Program(AB83030002019004)
Objective:Hydrogen sulfide(H_(2)S)has been elucidated that it promotes migration and invasion in human placenta trophoblasts.However,the signaling pathway underlying H_(2)S-based regulation of trophoblasts remains unk...
关键词：Hydrogen sulfide TROPHOBLAST PROLIFERATION MIGRATION INVASION Focal adhesion kinase signaling 
Human HAND1 inhibits the conversion of cholesterol to steroids in trophoblasts被引量：1
《Journal of Genetics and Genomics》2022年第4期350-363,共14页Haibin Zhu Qianlei Ren Ziyi Yan Shouying Xu Jiahao Luo Ximei Wu Chao Tang 
supported by Natural Science Foundation of Zhejiang Province (LY17H160023 to H.Z.);National Basic Research Program of China (973 Program, 2018YFC1004404 to X.W.);Starting Research Foundation from The Children’s Hospital,Zhejiang University School of Medicine (481);National Natural Science Foundation of China (31801207 to C.T.)
Steroidogenesis from cholesterol in placental trophoblasts is fundamentally involved in the establishment and maintenance of pregnancy.The transcription factor gene heart and neural crest derivatives expressed1(Hand1)...
关键词：HAND1 TROPHOBLAST CHOLESTEROL STEROIDS 
Viral Infections During Pregnancy:The Big Challenge Threatening Maternal and Fetal Health被引量：4
《Maternal-Fetal Medicine》2022年第1期72-86,共15页Wenzhe Yu Xiaoqian Hu Bin Cao 
supported by the grants from the National Key Research and Development Program of China(2018YFC1004400 to BC);the National Natural Sciences Foundation in China(81971414 and 82130047 to BC);the Natural Sciences Foundation of Fujian Province of China(2020J06003 to BC)。
Viral infections during pregnancy are associated with adverse pregnancy outcomes,including maternal and fetal mortality,pregnancy loss,premature labor,and congenital anomalies.Mammalian gestation encounters an immunol...
关键词：TROPHOBLASTS Congenital infection Hepatitis B virus Human immunodeficiency virus Influenza A virus Severe acute respiratory syndrome coronavirus 2 Zika virus 
A Defective CXCL16/CXCR6 Axis Increases the Risk of Pregnancy Loss via the Abnormal Crosstalk between Decidual γδ T Cells and Trophoblasts
《Reproductive and Developmental Medicine》2021年第3期129-139,共11页Deng-Xuan Fan Ming-Qing Li Wen-Jie Zhou Hong-Lan Huang Hui-Li Yang Cong-Jian Xu 
This study was supported by the National Natural Science Foundation of China(NSFC)(No.81300552,92057119,31970798);the Innovation-oriented Science and Technology Grant from NPFPC Key Laboratory of Reproduction Regulation(CX2017-2);the Program for Zhuoxue of Fudan University(JIF157602);the Support Project for Original Personalized Research of Fudan University.
Objective::The maternal-fetal interface undergoes dynamic changes to allow the fetus to grow and develop in the uterus.The interaction between decidualγδT cells and trophoblasts plays a pivotal role during successfu...
关键词：CXCL16 CXCR6 DecidualγδT Cells Maternal-fetal Interface Recurrent Spontaneous Abortion TROPHOBLASTS 
Aspirin Enhances the Protective Effect of Progesterone on Trophoblast Cell from Oxidative Stress and Apoptosis
《Reproductive and Developmental Medicine》2021年第1期1-8,共8页Jia-Wei Shi Hui-Li Yang Zhen-Zhen Lai Hui-Hui Shen Lu-Yu Ruan Yan Wang Xue-Min Qiu Feng Xie Ming-Qing Li 
This study was supported by the National Natural Science Foundation of China(No.31970798,31671200,82072872);the Innovation-oriented Science and Technology Grant from NPFPC Key Laboratory of Reproduction Regulation(CX2017-2);the Program for Zhouxue of Fudan University(JIF157602);the Support Project for Original Personalized Research of Fudan University.
Objective:Clinically,low-dose aspirin and progesterone are frequently used to prevent pregnancy loss.We investigated the effect of these drugs on the biological behavior of human extravillous trophoblasts in vitro.Met...
关键词：APOPTOSIS ASPIRIN Invasion MISCARRIAGE PROGESTERONE Progesterone Receptor Proliferation Reactive Oxygen Species TROPHOBLASTS 
Overexpression of LVRN impedes the invasion of trophoblasts by inhibiting epithelial–mesenchymal transition
《Acta Biochimica et Biophysica Sinica》2021年第2期249-257,共9页Xuan Feng Zhi Wei Sai Zhang Jiayi Zhou Jing Wu Baoxin Luan Yan Du Hongbo Zhao 
This work was supported by the grants from the National Natural Science Foundation of China(Nos.81971394 and 81571457);the Shanghai Pujiang Program(No.15PJ1400900).
Laeverin(LVRN)was first detected on the outer layer of the chorion laeve and migrating extravillous trophoblasts(EVTs).It is an enzyme that plays an important role in the placentation and pathophysiology of preeclamps...
关键词：LVRN extravillous trophoblast INVASION epithelial–mesenchymal transition lnc10-7 
Urothelial cancer associated 1(UCA1)regulates trophoblast viability,proliferation,and migration via modulating the UCA1/miR-455/RUNX2 signaling pathway被引量：1
《Acta Biochimica et Biophysica Sinica》2020年第10期1120-1130,共11页Xiaoying Xu Yufang Zhang Jing Li Baohong Mao 
This work was supported by the grant of the Gansu provincial Health research projects(No.GSWSKY2018-54).
Spontaneous abortion(SA)is the spontaneous loss of a pregnancy before 20 gestational weeks.The causes of SA are still largely unknown.Long noncoding RNA(lncRNA)urothelial cancer associated 1(UCA1)plays an important ro...
关键词：spontaneous abortion(SA) HTR-8/SVneo cells urothelial cancer associated 1(UCA1) TROPHOBLASTS ceRNA 
Upregulation of CD81 in trophoblasts induces an imbalance of Treg/Th17 cells by promoting IL-6 expression in preeclampsia被引量：19
《Cellular & Molecular Immunology》2019年第3期302-312,共11页Hailin Ding Yimin Dai Yi Lei Zhiyin Wang Dan Liu Ruotian Li Li Shen Ning Gu Mingming Zheng Xiangyu Zhu Guangfeng Zhao Yali Hu 
by the National Natural Science Foundation of China(81571462,81600353,and 81701472);Jiangsu Provincial Key Medical Center(YXZXB2016004);Jiangsu Biobank of Clinical Resources(BM2015004);Jiangsu Province Grant for Science and Technology(BK20161106).
The disturbance of maternal immune tolerance to a semiallogeneic fetus is recognized as one of the key pathologies of preeclampsia(PE),in which an imbalance between the inflammation-limiting regulatory T cells(Tregs)a...
关键词：CD81 PREECLAMPSIA TREG Th17 TROPHOBLASTS immune tolerance IL-6 
Trophoblast-derived CXCL16 induces M2 macrophage polarization that in turn inactivates NK cells at the maternal–fetal interface被引量：21
《Cellular & Molecular Immunology》2018年第12期1038-1046,共9页Xiao-Qiu Wang Wen-Jie Zhou Xin-Xin Hou Qiang Fu Da-Jin Li 
This study was funded by grant number MOST 2015CB943300 awarded to Da-Jin Li;a grant from the National Natural Science Foundation of China,number 81200425,awarded to Xiao-Qiu Wang;a grant from the National Natural Science Foundation of China,number 81471548,awarded to D.-J.L.;a grant from the National Natural Science Foundation of China,number 81571512,awarded to Q.F.;a grant from The Department of Science and Technology in Shandong Province,number ZR2015JL027,awarded to Q.F.
Decidual macrophages (dMΦ) are distinct from the conventional macrophages present in other tissues and express M2macrophage markers, but the molecular mechanisms of formation and the roles of M2 MΦ during pregnancy ...
关键词：CXCL16 TROPHOBLASTS macrophage polarization NK cells maternal-fetal interface 
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