Pluripotency of Induced Pluripotent Stem Cells  

作　　者：Chunjing Feng Yun-Dan Jia Xiao-Yang Zhao 

机构地区：[1]State Key Laboratory of Reproductive Biology,Institute of Zoology,Chinese Academy of Sciences [2]Key Laboratory of Translational Stem Cell Research,Institute of Zoology,Chinese Academy of Sciences [3]University of Chinese Academy of Sciences

出　　处：《Genomics, Proteomics & Bioinformatics》2013年第5期299-303,共5页基因组蛋白质组与生物信息学报（英文版）

基　　金：supported by grants from the National Basic Research Program of China(Grant No.2012CBA01300 and 2012CB966500)

摘　　要：Induced pluripotent stem （iPS） cells can be generated by forced expression of four pluripotency factors in somatic cells. This has received much attention in recent years since it may offer us a promising donor cell source for cell transplantation therapy. There has been great progress in iPS cell research in the past few years. However, several issues need to be further addressed in the near future before the clinical application of iPS cells, like the immunogenieity of iPS cells, the variability of differentiation potential and most importantly tumor formation of the iPS derivative cells. Here, we review recent progress in research into the pluripotency of iPS cells.Induced pluripotent stem （iPS） cells can be generated by forced expression of four pluripotency factors in somatic cells. This has received much attention in recent years since it may offer us a promising donor cell source for cell transplantation therapy. There has been great progress in iPS cell research in the past few years. However, several issues need to be further addressed in the near future before the clinical application of iPS cells, like the immunogenieity of iPS cells, the variability of differentiation potential and most importantly tumor formation of the iPS derivative cells. Here, we review recent progress in research into the pluripotency of iPS cells.

关 键 词：Induced pluripotent stemcells PLURIPOTENCY Cell transplantation therapy 

分 类 号：R329[医药卫生—人体解剖和组织胚胎学]