腺瘤性结肠息肉病基因D1822V单核苷酸多态性与结直肠癌风险的关系  

Association of colorectal cancer risk and the adenomatous polyposis coli D1822V variant： a meta-analysis

作　　者：方喜平[2] 冯茂辉 谢伟 陈双倩 王国洲 阳芳 柳琨 杨倩 陈大平 

机构地区：[1]恩施自治州中心医院肿瘤科,445000 [2]武汉大学中南医院肿瘤外科肿瘤生物学行为湖北省重点实验室,430071

出　　处：《中华实验外科杂志》2013年第11期2414-2416,共3页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金资助项目（81072152）;湖北省自然科学基金资助项目（2009CD201）;湖北省卫生厅科研资助项目（2013.JX6B20）;武汉市科技攻关重点资助项目（200860423230）

摘　　要：目的 探讨腺瘤性结肠息肉病（APC）基因D1822V单核苷酸多态性与结肠癌风险的关系.方法 以“APC基因”、“多态性”、“结直肠癌”、“D1822V”、“Asp1822Val”、“APC”、“polymorphism”、“D1822V”、“Asp1822Val”、“colorectal cancer”、“colorectal carcinoma”为主题词联合检索中国期刊全文数据库、重庆维普数据库、Medline、Pubmed等数据库.对所获得文献,按纳入、排除标准进行筛选,并对最终所获文献进行异质性和敏感性分析,并以比值比（OR）值为合并效应指标,利用软件进行综合Meta分析.结果 共纳入9篇文献,累计病例数8143例,对照数8776例.当Picelli的这项研究以普通人群为对照时,DV基因型和VV基因型同DD基因型比较,OR值及其95％可信区间分别为0.97（0.91 ～1.03）,0.89（0.77～ 1.03）；当以超级对照组为对照,其相应的值为0.96（0.90 ～ 1.03）、0.84（0.72 ～0.98）.结论 APC基因D1822V单核苷酸多态性,其VV基因型可能降低结直肠癌的风险.Objective To determine whether adenomatous polyposis coli （APC） D1822V variant predisposes to colorectal cancer. Methods NCBI, Medline, VIP, PubMed, ISI web of science and other Literature databases were searched by using the Medical Subjiect Heading term ＂ D1822V＂, ＂Asp1822Val＂ , ＂APC＂ , ＂polymorphism＂, ＂Asp1822V＂ , ＂colorectal cancer＂ , ＂ colorectal carcino- ma＂. Only case-control studies were included. The software Mata 4. 2 was used for data analysis. Results Nine studies, involving 8143 patients and 8776 controls were identified. APC D1822V did not show any difference between cases and controls, but when we considered to include Picelli＇ s study and considered only the super-control, the DV genetype was associated with an odds ratio of 0.96 （95% CI = 0.90-1.03 ） and VV genentype with an odds ratio of 0. 84 （95% C1 = 0. 72-0. 98 ）. Conclusion APC D1822V variant may reduce the risk of CRC development.

关 键 词：腺瘤性结肠息肉病基因 单核苷酸多态性 结直肠癌 META分析 

分 类 号：R735.3[医药卫生—肿瘤]