卵圆孔未闭与中老年人隐源性卒中关系的Meta分析  

A Meta-analysis on relationship between patent foramen ovale and cryptogenic stroke in middle aged and elderly people

作　　者：马冰[1] 陈欣[1] 刘奕婷[1] 张建明[1] 时景璞[1] 

机构地区：[1]中国医科大学附属第一医院临床流行病与循证医学教研室,沈阳110001

出　　处：《中国循证心血管医学杂志》2013年第5期453-456,共4页Chinese Journal of Evidence-Based Cardiovascular Medicine

摘　　要：目的：研究卵圆孔未闭（PFO）与中老年隐源性卒中的关系，为中老年隐源性卒中的病因探索提供依据。方法通过检索PubMed、Embase、Web of Science、中国学术期刊网、维普中文科技期刊全文数据库、万方科技期刊全文数据库，选择有关卵圆孔未闭与中老年隐源性卒中的病例对照研究，采用Meta分析方法，通过Stata11.0软件评价两者之间的关系。结果共检索到10篇病例对照研究。Meta分析结果显示，卵圆孔未闭是隐源性卒中的危险因素（OR=2.09，95%CI：1.61～2.71）。单独对经过调整后的OR值合并得到的效应值为2.65（95%CI：1.81～3.88），结果具有统计学意义。亚组分析显示，按照患者年龄下限（55岁）分组后，下限值＜55岁组的效应值降为1.37，达到临界效应（95%CI：1.00～1.88）。按发表时间、对照人群、卒中诊断方法、PFO诊断方法分组后，各亚组的效应值没有发生较大变化，均具有统计学意义（P＜0.05）。结论卵圆孔未闭可能是中老年隐源性卒中的危险因素。Objective To study the relationship between patent foramen ovale （PFO） and cryptogenic stroke in middle aged and elderly people, and provide the evidence for etiological research of cryptogenic stroke. Methods The databases of PubMed, Embase, Web of Science, CNKI, VIP and WanFang were retrieved for selecting the case-controlled trials about PFO and cryptogenic stroke in middle aged and elderly people. The relationship between PFO and cryptogenic stroke were analyzed and reviewed by using Meta-analysis and Stata11.0 software. Results There were totally 10 trials obtained. The results of Meta-analysis showed that PFO was the risk factor of cryptogenic stroke （OR=2.09, 95%CI：1.61-2.71）. The effect size gotten from pooled OR after adjusting separately was 2.65 （95%CI： 1.81-3.88） which had statistical significance. The results of subgroup analysis showed that the effect size decreased to 1.37 and reached a threshold effect （95%CI：1.00-1.88） in group aged below limiting value〈55 after grouping according to the age lower limit （55 years old） of the patients. The effect sizes had no changes in all subgroups （P〈0.05） after grouping according to publishing time, control group, stroke diagnostic method and PFO diagnostic method. Conclusion PFO may be a risk factor of cryptogenic stroke in middle aged and elderly people.

关 键 词：卵圆孔未闭 中老年人 隐源性卒中 META分析 

分 类 号：R743.3[医药卫生—神经病学与精神病学]