蛋白磷酸酶2A癌性抑制因子在结直肠癌组织芯片中的表达及临床意义  

Expression of cancerous inhibitor of protein phosphatase 2A in tissue microarray of colorectal cancer and its clinical significance

作　　者：彭星宇[1] 陈伟[3] 周凯[2] 符建平[1] 傅平[2] 曾庆黎[1] 

机构地区：[1]江西省人民医院普通外科,南昌330006 [2]江西省人民医院干部外科,南昌330006 [3]南昌大学医学院

出　　处：《中华胃肠外科杂志》2013年第11期1102-1106,共5页Chinese Journal of Gastrointestinal Surgery

基　　金：国家自然科学基金地区科学基金（81260368）;江西省科技厅资助项目（2010BSA14200）

摘　　要：目的探讨结直肠癌组织中蛋白磷酸酶2A癌性抑制因子（CIP2A）的表达及其临床意义。方法采用免疫组织化学方法检测92例结直肠癌组织芯片中CIP2A的表达情况，分析其表达与患者临床病理因素及预后之间的关系。结果CIP2A高表达与肿瘤TNM分期、组织分型、腹膜种植及肝转移有关（P〈0．05）；但与患者性别、年龄、肿瘤部位、CEA、结直肠癌家族史及分化程度无关（P〉0．05）。CIP2A高表达组1、3、5和10年总生存率分别为97．1％、71．4％、59．2％和44．4％，明显低于低表达组的98．2％、85．7％、80．3％和74．9％，两者差异具有统计学意义（P=0．021）。多因素生存分析显示，CIP2A高表达并非是影响结直肠癌的独立不良预后因素（P=0．099，HR=1．982，95％CI：0．879-4．469）。结论CIP2A高表达与结直肠癌的临床病理特征密切相关，CIP2A可能成为潜在的结直肠癌转移和预后分子标志物或治疗靶点。Objective To investigate the expression of cancerous inhibitor of protein phosphatase 2A（CIP2A） in human colorectal cancer, and to examine the association of CIP2A expression with clinicopathology and prognosis. Methods CIP2A expression in colorectal cancer tissue microarray of 92 cases was detected by immunohistochemistry method. Results Up-regulated CIP2A expression was closely related with TNM staging, histological type, peritoneal seeding and liver metastasis （all P〈0.05）, but not related with gender, age, tumor location, CEA, family history and grade of differentiation. Overall survival rates of 1-, 3-, 5-, and 10-year in high CIP2A expression group were 97.1%, 71.4%, 59.2%, and 44.4% respectively, significantly lower than 98.2%, 85.7%, 80.3%, and 74.9% in low CIP2A expression group（P=0.021）. Multivariate analysis showed that CIP2A was not an independent factor associated with prognosis （P=0.099, HR=1.982, 95%CI：0.879 to 4.469）. Conclusions Up-regulated CIP2A expression is closely related to clinicopathology of colorectal cancer. CIP2A may be used as a potential predictive marker of metastasis, prognosis and therapeutic target in colorectal cancer.

关 键 词：结直肠肿瘤 蛋白磷酸酶2A癌性抑制因子 组织芯片 免疫组织化学 

分 类 号：R735.3[医药卫生—肿瘤]