CTVision图像引导下非小细胞肺癌立体定向放疗的精确性分析  

Evaluation of the accuracy of CTVision image-guided stereotactic body radiation therapy for non-small cell lung cancer

作　　者：郑晓丽[1] 叶柯[1] 毛荣虎[1] 杨成梁[1] 翟冲亚 邱荣良[1] 葛红[1] 

机构地区：[1]郑州大学附属肿瘤医院河南省肿瘤医院放疗科,450003

出　　处：《中华放射肿瘤学杂志》2013年第6期485-488,共4页Chinese Journal of Radiation Oncology

基　　金：河南省国际合作项目（124300510016）;河南省部共建项目（201201009）

摘　　要：目的 探讨CTVision引导下非小细胞肺癌立体定向放疗的精确性.方法 2010-2012年应用西门子ONCOR CTVision加速器对10例非小细胞肺癌患者行立体定向放疗,采集每位患者每次放疗前后CT图像并与治疗计划CT图像进行匹配,在线调整并分析患者放疗前后位移误差.通过离线勾画每位患者每次放疗前后（共8次）大体肿瘤体积,融合8次靶区得到内靶体积,通过比较内靶体积和计划靶体积进行离线验证治疗过程准确性.配对样本t检验差异.结果 分析10例肺癌患者放疗前后80次CT扫描数据,结果显示放疗前和后在左右、上下、前后方向位移误差均相似,分别为（-0.10±1.30）mm和（-0.15±1.31）mm （P =0.720）、（0.18±1.32） mm和（0.18±1.43） mm （P=1.000）、（-0.08±1.19）mm和（-0.13±1.18）mm （P=0.750）.内靶区的体积均小于计划靶区体积,分别为13.53 cm3和37.84 cm3（p =0.000）.结论 CTVision加速器能够确保肺癌患者立体定向放疗的准确性和安全性.Abstract： Objective To investigate the accuracy of CTVision image-guided stereotactic body radiation therapy （SBRT） for non-small cell lung cancer （NSCLC）.Methods 10 lung SBRT patients were imaged with CTVision before and after irradiation for acquiring and analyzing the three-dimensional set-up error data sets in our department from October 2010 to May 2012.Gross tumor volumes （GTVs） were contoured on pre-and post-SBRT CT sets and combined for generating internal gross tumor volumes （IGTVs）.Planning target volume （PTV） margin was calculated,and IGTVs and PTVs were compared for off-line verification of accuracy of SBRT.A paired t-test statistical analysis was conducted with the datasets using SPSS 17.0.Results 80 CT image sets were totally obtained.Setup errors was significant difference before and after radiotherapy in the left-right,superior-inferior and anterior-posterior directions,that were （-0.10±1.30） mmand （-0.15±1.31） mm （P=0.720）,（0.18±1.32） mm and （0.18±1.43） mm （P =1.000） and （-0.08 ± 1.19） mm and （-0.13 ± 1.18） mm （P =0.750）,respectively.IGTVs of ten patients were smaller than corresponding PTVs （13.53 cm3 and 37.84 cm3,P =0.000）.Conclusion Accuracy and safety of SBRT could be verified by imaging with CTVision before and after delivery for non-small cell lung cancer.

关 键 词：癌 非小细胞肺 立体定向放射疗法 位移误差 

分 类 号：R734.2[医药卫生—肿瘤]