继发性胶质母细胞瘤的MR表现  

MRI Features of Secondary Glioblastoma

作　　者：赵茜茜[1] 许乙凯[1] 张嘉君[1] 黄丽霞[1] 刘香[1] 

机构地区：[1]南方医科大学南方医院影像中心,广州510515

出　　处：《临床放射学杂志》2013年第11期1551-1555,共5页Journal of Clinical Radiology

摘　　要：目的探讨继发性胶质母细胞瘤的MR表现。方法回顾性分析12例经病理证实的继发性胶质母细胞瘤的MR表现。结果12例患者共发现16处复发病灶，其中12处经病理证实为胶质母细胞瘤，均表现出由低级别胶质瘤向胶质母细胞瘤恶性演变的过程；从低级别胶质瘤发展到胶质母细胞瘤的间隔时间为6个月-20年不等，平均为5．5年。复发病灶主要呈稍长T2、长T2信号，多数信号较为混杂，伴有明显的出血坏死（n=10）、囊变（n=6），复发瘤多位于原发灶2cm范围内（n=11），增强扫描呈不均匀明显强化。结论继发性胶质母细胞瘤MR表现有一定特征，并且有较低级别胶质瘤术后多次复发的病史，结合影像学上明显恶性进展的表现，诊断继发性胶质母细胞瘤并不困难。Objective To study MRI features of secondary glioblastoma. Methods MRI features of 12 cases with secondary glioblastoma confirmed by postoperative pathology were analyzed restrospectively. Results A total of 16 recur rent lesions were found in 12 patients, among them, 12 lesions were histologically confirmed glioblastoma. 12 cases of sec ondary glioblastoma were presented as clinical （neuroimaging） and histologic evidences of evolution from low grade to high grade glioma. The course of progression varied considerably, with time intervals ranging from 6 months to 20 years, the mean time was 5.5 years. 11 lesions were located in the area of 2 cm from the precursor lesions. Secondary glioblastoma presented as heterogeneous intensity, most of them with cysts （ n = 6） and necrosis （ n = 10）. 2 patients had 3 satellite le sion. All the lesions were enhanced unevenly. Conclusion Secondary glioblastomas have certain characteristic MR fea tures, and it is not difficult to make a correct diagnosis combining with the history of evolution from a less malignant precur sor lesion.

关 键 词：继发性 胶质母细胞瘤 磁共振成像 组织病理学 

分 类 号：R739.4[医药卫生—肿瘤]