乳腺癌磁共振特征与HER-2表达的相关性  

Correlation on MRI Features and HER-2 Expression of Breast Cancer

作　　者：杨丽[1] 时高峰[1] 刘辉[1] 周涛[2] 

机构地区：[1]河北医科大学第四医院CT/MR室,石家庄050011 [2]河北医科大学第四医院乳腺中心,石家庄050011

出　　处：《肿瘤防治研究》2013年第11期1070-1073,共4页Cancer Research on Prevention and Treatment

基　　金：河北省高校强势特色学科基金资助项目(冀教高[2005]52号)

摘　　要：目的分析乳腺癌磁共振(MRI)形态学、早期强化率及表观扩散系数(ADC)与HER-2表达的相关性。方法对63例手术证实的乳腺癌患者的乳腺MRI特征与HER-2表达进行分析。观察乳腺癌MRI形态学特征,计算肿物早期强化率及ADC值,应用χ2检验及Spearman秩相关分析分析其与HER-2表达的相关性。结果乳腺癌肿有无坏死与HER-2高表达率有关,有坏死组高表达率较无坏死组明显增高,差异有统计学意义(χ2=4.257,P=0.039)。乳腺癌肿边缘是否光滑与HER-2高表达率无关(χ2=0.100,P=0.921)。乳腺癌早期强化率与HER-2表达水平无关(r=0.159,P=0.215)。乳腺癌ADC值与HER-2表达水平呈负相关(r=-0.366,P=0.003)。结论乳腺癌MRI征象可以从一定程度上反映肿瘤HER-2蛋白的表达水平。Objective To investigate the correlations among MRI morphologic feature, the early-phase enhancement rate, apparent diffusion coefficient （ADC） and HER-2 of breast cancer. Methods Sixty- three patients diagnosed as breast cancers by pathologic examination were reviewed, including MR/features and the expression of HER-2. The morphologic features were observed in early phase. The early-phase enhancement rate and the value of ADC were also calculated. All statistical analyses were performed by using SPSS 11.5. Results In the cases with breast cancer, the high expression rate of HER-2 had correlation with necrosis, with higher overexpression rate in patients with necrosis than in the others（z2 = 4.257, P = 0.039）. The high expression rate of HER-2 had no correlation with the margin（X2= 0.100, P = 0.921）. The expression rate of HER-2 had no correlation with the early-phase enhancement rate（r = 0.159, P = 0.215）. The value of ADC had negative correlation with the expression rate of HER-2（r = -0.366, P = 0.003）.Conclusion MRI features can reflect the expression of HER-2 in breast cancer partly.

关 键 词：乳腺癌 磁共振成像 HER-2 

分 类 号：R737.9[医药卫生—肿瘤] R445.2[医药卫生—临床医学]