O-羧甲基壳聚糖稳定性研究  

Study on the Stability of O-Carboxymethyl Chitosan

作　　者：吴迪[1,2] 浦金辉[1] 刘辉[1] 张婧[1,2] 邹萍[1,2] 

机构地区：[1]广州军区武汉总医院药剂科,武汉430070 [2]湖北中医药大学药学院2010级研究生班,武汉430065

出　　处：《医药导报》2013年第11期1494-1496,共3页Herald of Medicine

基　　金：武汉市科技攻关计划(200960323135);全军医学科研“十二五”计划课题(CWS11C274)

摘　　要：目的考察自制O-羧甲基壳聚糖(O-CMC)的稳定性。方法采用旋转黏度计测定O-CMC的特性,黏度作为稳定性考察指标,比较O-CMC在不同pH、不同离子强度、紫外线照射、温度等条件下的稳定性。结果 O-CMC的特性黏度随pH的降低而降低;溶液离子强度越大,O-CMC特性黏度越小;随紫外线照射时间的延长,O-CMC的特性黏度逐渐变小;随37℃培养条件下应用时间延长,O-CMC特性黏度逐渐降低。结论酸碱度、离子强度、紫外线照射、温度对O-CMC的稳定性均有较大影响。Objective To investigate the stability of self-made O-carboxymethyl chitosan（O-CMC）. Methods The rotary viscosimeter was applied to evaluate the property and stability indicated as intrinsic viscosities of O-CMC under conditions as various pH, ionic strength, ultraviolet radiation and heat. Results The intrinsic viscosities of O-CMC decreased as pH decreased or ionic strength increased, and the intrinsic viscosities decreased as ultraviolet radiation lasted and cultivated longer under 37℃. Conclusion The pH,ionic strength, ultraviolet radiation and temperature all affect the stability of O-CMC.

关 键 词：O-羧甲基壳聚糖 黏度 稳定性 

分 类 号：R286[医药卫生—中药学] R94[医药卫生—中医学]