FAS-1377基因多态性与青海地区乳腺癌临床病理指标的关系  

Association between FAS-1377 gene polymorphisms and clinical pathological index of breast cancer in Qinghai district

作　　者：金丽艳[1] 胡英[2] 黄欣[2] 王秀娟[2] 张双元[1] 

机构地区：[1]青海大学附属医院,西宁810000 [2]青海大学医学院

出　　处：《山东医药》2013年第34期4-6,共3页Shandong Medical Journal

基　　金：国家自然科学基金资助项目(30960359)

摘　　要：目的探讨凋亡基因FAS-1377基因多态性与青海地区乳腺癌临床病理指标的关系。方法采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)分析方法,检测233例乳腺癌患者的FAS-1377基因多态性,并分析基因多态与乳腺癌临床指标之间的关系。结果 FAS-1377基因纯合野生型GG分布频率为21.0%(49/233)、杂合型GA为56.7%(132/233)、纯合突变型AA为22.3%(52/233)。乳腺癌患者FAS-1377基因多态性与临床病理指标无统计学意义。结论 FAS-1377基因多态性与青海地区乳腺癌患者临床病理指标无明显相关性。Objective To investigate the correlation between FAS-1377 gene polymorphisms and clinic pathological index of breast cancer in Qinghai district.Methods The polymorphisms of FAS-1377 gene were detected by polymerase chain reaction-restriction fragment length polymorphisms assay （PCR-RFLP） in 233 female patients with breast cancer,x2 was applied to assess the association between the polymorphisms of FAS-1377 gene and clinic pathologic index of breast cancer.Results The frequencies of FAS-1377 GG （homozygous wild type）,GA （heterozygous type） and AA （homozygous mutant type） were respectively 21.0％ （49/233）,56.7％ （132/233） and 22.3 ％ （52/233）.No statistical significance was found between FAS-1377 gene polymorphisms and clinic pathological index of breast cancer （P≥0.05）.Conclusion The polymorphisms of FAS-1377 gene is not associated with clinic pathological index of breast cancer in Qinghai district.

关 键 词：乳腺癌 FAS-1377 基因多态 临床病理指标 

分 类 号：R73[医药卫生—肿瘤]