双室袋法与注射器法配制静脉输液的不溶性微粒比较  

Comparison of Insoluble Particles in Intravenous Infusion through 2-chamber Drug Delivery System Method and Syringe Method

作　　者：李英[1,2] 王宇航[3] 赵立波[1] 冯婉玉[1] 

机构地区：[1]北京大学人民医院药剂科,北京100044 [2]北京大学药学院药事管理与临床药学系,北京100191 [3]中国医科大学药学院药物分析教研室,沈阳110001

出　　处：《中国药学杂志》2013年第22期1969-1971,共3页Chinese Pharmaceutical Journal

摘　　要：目的评价双室袋法与注射器法配制静脉输液在临床使用的安全性差异。方法采用光阻法分别测定配制前粉体、液体和双室袋法或注射器法配制后混合液共880份样品中不溶性微粒的大小和数量,考察两种配制方法对溶液不溶性微粒的影响。结果注射器法配制后各粒径不溶性微粒大小和数量显著增加,P<0.05;双室袋法配制后不增加溶液中不溶性微粒数量;注射器法配制溶液所含≥10μm不溶性微粒数量明显多于双室袋法溶液,P<0.05。结论双室袋法较注射器法可显著减少溶配过程中引入不溶性微粒,且不受配液环境影响,临床用药安全性更佳。OBJECTIVE To evaluate the clinical safety differences between 2-chamber drug delivery system method and syringe method in preparation of intravenous fluids. METHODS The light blockage method was used to record the count of insoluble particals in samples of before and after preparation through the 2-chamber drug delivery system method or syringe method. RESULTS After preparation by the syringe method, the number of insoluble particles of each particle size increased significantly, P 〈 0. 05 ; while the 2-cham- ber drug delivery system method does not increase the insoluble particle number after preparation ; the solution contains significantly more i〉 10 p,m insoluble particles in the syringe method than in the 2-chamber drug delivery system method, P 〈0. 05. CONCLUSION 2- Chamber drug delivery system method can significantly reduce the introduction of insoluble particles in the process of intravenous infusion preparation comparing with the syringe method, and despite of what the environment is, has a better clinical safety.

关 键 词：双室袋 不溶性微粒 光阻法 静脉输液 

分 类 号：R95[医药卫生—药学]