HLA-DRB1和HLA—DQB1基因与肿瘤的关联性研究  

A relevance between tumor and HLA-DRB1 and HLA.DQB1 gene polymorphism

作　　者：周秀英[1] 于雅宁[1] 刘辉[2] 

机构地区：[1]威海市文登中心医院检验科,264400 [2]大连医科大学临床免疫学教研室,116027

出　　处：《国际免疫学杂志》2013年第6期488-490,共3页International Journal of Immunology

摘　　要：目的通过对42例肿瘤患者HLA-DRBl和HLA—DQB1座位的18个等位基因位点的检测，探讨HLA—DRB1和HLA—DQB1基因多态性与肿瘤的关联性。方法采用PCR—SSP技术，检测42例肿瘤患者的HLA—DRB1l和HLA—DQB1基因位点18个，并以100例健康人作为对照。结果肿瘤HLA—DQB1＊03型频率的65．5％，高于对照组的42．0％，RR=2．62，P〈0．0001；肿瘤组HLA—DQB1％06型频率为10．7％，明显低于对照组的24．0％，RR=0．38，P=0．010。结论HLA-DQB1＊03可能是肿瘤的易感基因，HLA-DQB1＊06可能是肿瘤的抗性基因。Objective To study the relevance between tumor and HLA-DRB1 and HLA-DQB1 gene poly-morphism via analyzing 18 alleles of HLA-H gene locus of some tumor patients. Methods 18 alleles of HLA-Ⅱ gene locus of 42 tumor patients were analyzed and compared .with those of 100 healthy people using PCR-SSP （polymerase chain reaction-sequence specific primers） technology. Results The HLA-DQB1 ＊ 03 frequency of the tumor group was 65.5%, it was significantly higher than the 42.0% of the control group, RR = 2. 62, P 〈0. 0001; the HLA-DQB1 ＊ 06 frequency of tumor group was 10.7%, it was significantly lower than 24.0% of the control group ,RR = 0. 38 ,P value was of 0.010. Conclusion It is suggested that HLA-DQB1 ＊ 03 may be the susceptibility gene of tumor, HLA-DQB1 ＊ 06 may be the resistance genes of tumor.

关 键 词：HLA 抗原 肿瘤 基因 

分 类 号：R730.2[医药卫生—肿瘤]