肠淋巴系统在急性胰腺炎中的研究进展  

Role of intestinal lymphatic system in pathogenesis of acute pancreatitis

作　　者：刘媛琪[1] 熊玉霞[1] 

机构地区：[1]泸州医学院药学院药理教研室,四川省泸州市646000

出　　处：《世界华人消化杂志》2013年第30期3211-3216,共6页World Chinese Journal of Digestology

基　　金：国家自然基金资助项目;No.81102868~~

摘　　要：急性胰腺炎(acute pancreatitis,AP)是临床常见的急腹症,发病机制复杂.肠淋巴系统在AP的发展中起着重要作用.肠淋巴通道是肠道细菌、内毒素移位的重要途径.肠淋巴液中含有的内毒素诱导众多炎症因子的表达,肿瘤坏死因子、白介素等细胞因子水平的上调,都加重胰腺损伤.肠淋巴细胞在肠免疫功能的维持中发挥了重要作用.因此对肠淋巴系统在AP中的作用进行探讨具有重要意义.Acute pancreatitis is a common severe disease involving a complicated cascade of events. The intestinal lymphatic system plays an important role in the development of acute pancreatitis. The intestinal lymph channel is an important pathway for bacterial translocation and endotoxin translocation. The entry of endotoxin into the intestinal lymph system induces the expression of numerous inflammatory factors and cytokines. The increase in tumor necrosis factors （TNFs） and interleukins （ILs） aggravates acute pancreatic injury. Intestinal lymphocytes also play an important role in maintaining a balance of intestinal immune function. Therefore, it is of great significance to understand the role of the intestinal lymph system in the pathogenesis of acute pancreatitis.

关 键 词：急性胰腺炎 肠淋巴 内毒素 肿瘤坏死因子 白介素类 

分 类 号：R576[医药卫生—消化系统]