NF-κB和VEGF-C在“三阴”型乳腺癌中的表达及临床意义  

Expressions and clinical significance of NF-κB and VEGF-C in triple-negative breast cancer

作　　者：韩中保[1] 杨友田[2] 韩扣兰[3] 戴小丽[3] 

机构地区：[1]盐城卫生职业技术学院解剖学教研室,江苏省224006 [2]盐城卫生职业技术学院继续教育学院,江苏省224006 [3]盐城卫生职业技术学院临床教研室,江苏省224006

出　　处：《江苏医药》2013年第21期2576-2578,共3页Jiangsu Medical Journal

基　　金：江苏省盐城市医学科技发展计划项目(YK2011119)

摘　　要：目的探讨核因子κB(NF-κB)与血管内皮生长因子C(VEGF-C)在"三阴"型乳腺癌(TNBC)与"非三阴"型乳腺癌(N-TNBC)中的表达及其临床意义。方法应用免疫组织化学SP法检测TNBC患者(A组,76例)和N-TNBC对照患者(B组,128例)癌组织中NF-κB和VEGF-C的表达,分析其与临床病理特征的关系。结果两组NF-κB和VEGF-C表达均与肿瘤组织学分级、临床分期和淋巴结转移相关(P<0.05)。A组NF-κB和VEGF-C的阳性率分别为78.9%和67.1%,高于B组的71.1%和64.8%。两组NF-κB与VEGF-C的表达均呈正相关。结论 NF-κB与VEGF-C在TNBC中高表达,可能在促进肿瘤的生长、浸润及转移中起作用。Objective To investigate the expressions and clinical significance of nuclear factor kappa B（NF-κB） and vascular endothelial growth factor-C（VEGF-C） in patients with triple-negative breast cancer（TNBC） and non-triple-negative breast cancer（N-TNBC）. Methods The expressions of NF-κB and VEGF-C were detected by immunohistochemistry SP method in 76 cases of TNBC（group A） and 128 cases of N-TNBC （group B）. The correlation between the expressions and clinicopathological characteristics was analyzed. Results The expressions of NF-κB.and VEGF-C had a close relationship with tumor grade, clinical stage and lymph node metastasis in both groups （P〈0. 05）. The positive expression rates of NF-κB and VEGF-C in group A were 78. 9% and 67.1%,which were higher than 71.1% and 64.8% in group B. There was a positive correlation between expressions of NF-κB and VEGF-C in both groups （P〈0. 05）. Conclusion NF-κB and VEGF-C are highly expressed in TNBC, which may play an importent role in tumor growth, invasion and metastasis.

关 键 词：乳腺癌 核因子ΚB 血管内皮生长因子C 

分 类 号：R737[医药卫生—肿瘤]