2型糖尿病视网膜病变与血管内皮生长因子的关系  

Association of diabetic retinopathy and vascular endothelial growth factor in type 2 diabetes mellitus

作　　者：葛倩[1] 严国明[1] 季飞[1] 

机构地区：[1]盐城市第三人民医院眼科,江苏省224006

出　　处：《江苏医药》2013年第21期2592-2593,共2页Jiangsu Medical Journal

摘　　要：目的探讨2型糖尿病(T2DM)视网膜病变与血管内皮生长因子(VEGF)的关系。方法在T2DM患者180例(糖尿病组)和健康人110名(对照组)进行眼底荧光血管造影(FFA)检查,并用ELISA法测定血VEGF含量。结果根据FFA检查结果,糖尿病组分为三组:NDR组56例,无视网膜病变;BDR组89例,有背景性糖尿病视网膜病变;PDR组35例,增殖性糖尿病视网膜病变。三组血清VEGF含量分别为(166.8±35.8)pg/ml,(235.7±50.7)pg/ml和(208.7±40.8)pg/ml,均明显高于对照组的(101.2±28.3)pg/ml(P<0.01)。结论 VEGF是糖尿病视网膜病变发生的重要因素之一。Objective To observe the relationship between diabetic retinopathy （DR） and vascular endothelial growth factor（VEGF） in patients with type 2 diabetes mellitus（T2DM）. Methods The fluorescence fundus angiography （FFA） examination was performed and serum VEGF was detected with ELISA in 108 T2DM patients and 110 healthy people（group C）. Results On the basis of FFA,108 T2DM patients were assigned into three groups of NDR（56 cases,without DR） ,BDR（89 cases,with background DR） and PDR（35 cases, with proliferative DR）. Serum levels of VEGF in groups of NDR,BDR and PDR were （166.8±35.8） pg/ml, （235.7±50. 7） pg/ml and （208. 7±40. 8） pg/ml, respectively, which were significantly higher than （101.2± 28.3） pg/ml in group C （P〈0. 01）. Conclusin VEGF is one of the important factors for the occurrence of DR.

关 键 词：视网膜病变 2型糖尿病 血管内皮生长因子 

分 类 号：R774[医药卫生—眼科]