Yin and Yang of ginseng pharmacology： ginsenosides vs gintonin  

作　　者：Dong-soon IM Seung-yeol NAH 

机构地区：[1]Molecular Inflammation Research Center for Aging Intervention (MRCA) and College of Pharmacy, Pusan National University, Busan 609- 735, Korea [2]Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University, Seou1143-701, Korea

出　　处：《Acta Pharmacologica Sinica》2013年第11期1367-1373,共7页中国药理学报（英文版）

摘　　要：Ginseng, the root of Panaxginseng, has been used in traditional Chinese medicine as a tonic herb that provides many beneficial effects. Pharmacologic studies in the last decades have shown that ginsenosides （ginseng saponins） are primarily responsible for the actions of ginseng. However, the effects of ginseng are not fully explained by ginsenosides. Recently, another class of active ingredients called gintonin was identified. Gintonin is a complex of glycosylated ginseng proteins containing lysophosphatidic acids （LPAs） that are the intracellular lipid mitogenic mediator. Gintonin specifically and potently activates the G protein-coupled receptors （GPCRs） for LPA. Thus, the actions of ginseng are now also linked to LPA and its GPCRs. This linkage opens new dimensions for ginseng pharmacology and LPA therapeutics. In the present review, we evaluate the pharmacology of ginseng with the traditional viewpoint of Yin and Yang components. Furthermore, we will compare ginsenoside and gintonin based on the modern view of molecular pharmacology in terms of ion channels and GPCRs.Ginseng, the root of Panaxginseng, has been used in traditional Chinese medicine as a tonic herb that provides many beneficial effects. Pharmacologic studies in the last decades have shown that ginsenosides （ginseng saponins） are primarily responsible for the actions of ginseng. However, the effects of ginseng are not fully explained by ginsenosides. Recently, another class of active ingredients called gintonin was identified. Gintonin is a complex of glycosylated ginseng proteins containing lysophosphatidic acids （LPAs） that are the intracellular lipid mitogenic mediator. Gintonin specifically and potently activates the G protein-coupled receptors （GPCRs） for LPA. Thus, the actions of ginseng are now also linked to LPA and its GPCRs. This linkage opens new dimensions for ginseng pharmacology and LPA therapeutics. In the present review, we evaluate the pharmacology of ginseng with the traditional viewpoint of Yin and Yang components. Furthermore, we will compare ginsenoside and gintonin based on the modern view of molecular pharmacology in terms of ion channels and GPCRs.

关 键 词：GINSENG GINSENOSIDE gintonin lysophosphatidic acid ion channels G protein-coupled receptors Ca2＋ traditional Chinesemedicine 

分 类 号：Q51[生物学—生物化学] O629.13[理学—有机化学]