新疆喀什伽师县农村维吾尔族男性HPV感染分布研究  

On distribution of HPV subtypes among male Uyghur in Payzawat,Kashgar

作　　者：穆娅斯尔.吐尔干 张璐[2] 古扎丽努尔.阿不力孜 高冬梅[2] 马丽华[2] 

机构地区：[1]新疆医科大学附属肿瘤医院妇六科,乌鲁木齐830011 [2]新疆医科大学附属肿瘤医院妇外五科,乌鲁木齐830011

出　　处：《新疆医科大学学报》2013年第11期1650-1653,共4页Journal of Xinjiang Medical University

基　　金：国家自然科学基金(30860325)

摘　　要：目的探讨新疆喀什伽师县农村维吾尔族男性HPV感染的分布及亚型特点,为新疆维吾尔族妇女HPV干预及宫颈癌预防提供理论依据。方法采用凯普导流杂交芯片技术对新疆宫颈癌高发区新疆喀什伽师县克孜勒博依乡430例维吾尔族男性进行21种HPV亚型的检测。结果 (1)430例男性HPV阳性率为26.28%,HPV阳性的男性中HPV16是最常见的类型,与其他类型比较阳性率差异有统计学意义(P<0.05)。(2)HPV感染的类型主要为16、58、31型;多重感染者15例,占HPV感染者的13.27%(15/113),多重感染以HPV16型合并感染为主,占86.67%(13/15)。结论新疆喀什伽师县克孜勒博依乡维吾尔族男性HPV阳性率较高,HPV感染的类型以HPV16为主,维吾尔族男性在维吾尔族宫颈癌发生中可能起一定作用。Objective To provide a theoretical basis for HPV intervention and cervical cancer prevention in Uyghur women By investigating the distribution of infection of human papilloma virus （HPV） in Uyghur men in Payzawat county - a cervical cancer epidemic area. Methods HPV was tested in 430 cases of Uy- ghur men in Kezbol township, Payzawat, Kashgar by using Hybrimax method. All the experimental data were input in Excel and SPSS 13.0 was adopted to analyze the data. Results （1） Among the 430 cases, HPV positive are 26.28%, among which HPV16 is the most prevalent subtype and the difference is the statistically significant （P d0.05）. （2） The principle subtypes are HPV16, HPV58 and HPV31. 15 cases （13.27%） have the HPV multiple infections in all positive cases, among which, HPV16 was the prevalent subtype in HPV combination infections among the multiple infections with the rate of 86.67% （13/15）. Conclusion The rate of HPV positive in Uyghur men in Kezbol township, Payzawat, Kashgar was rela- tively higher, among which, HPV 16 was the most prevalent subtype. Uyghur males may play the part in the occurrence of cervical cancer in Uyghur females.

关 键 词：HPV 维吾尔族 男性 宫颈癌 凯普导流杂交技术 

分 类 号：R737.33[医药卫生—肿瘤]