Variation in Expression of Insulin-like Growth Factors( IGFs) System Genes in Ovarian and Uterine Tissues of Aging Rats  

作　　者：Min WEI Wenwen RU Ye LV 

机构地区：[1]Institute of Botany,Jiangsu Province and Chinese Academy of Sciences

出　　处：《Agricultural Biotechnology》2013年第5期32-35,共4页农业生物技术（英文版）

基　　金：Supported by National Natural Science Foundation of China(30973927)

摘　　要：Variations in expression of insulin-like growth factors （IGFs） system genes in rat ovarian and uterine tissues were investigated by real-time quantitative PCR amplification using RT2 ProfilerTM PCR Array Rat Insulin Signaling Pathway （PARN-030A） chips. According to results of gene detection, a total of 15 differeutially expressed genes were screened in ovarian tissues, including 3 upregulated genes and 10 downregulated genes; a total of 22 differentially expressed genes were screened in uterine tissues, including 5 upregulated genes and 17 downregulated genes. These differentially expressed genes might be related to the insulin resistance.Variations in expression of insulin-like growth factors （IGFs） system genes in rat ovarian and uterine tissues were investigated by real-time quantitative PCR amplification using RT2 ProfilerTM PCR Array Rat Insulin Signaling Pathway （PARN-030A） chips. According to results of gene detection, a total of 15 differeutially expressed genes were screened in ovarian tissues, including 3 upregulated genes and 10 downregulated genes; a total of 22 differentially expressed genes were screened in uterine tissues, including 5 upregulated genes and 17 downregulated genes. These differentially expressed genes might be related to the insulin resistance.

关 键 词：AGING Gene chip OVARY UTERUS Insulin-like growth factor 

分 类 号：R711.75[医药卫生—妇产科学]