化痰消瘀方用于胃癌癌前病变的疗效观察  

Efficacy observation of“Xiaoyu Huatan Chinese Medicine”on precancerous lesions of gastric cancer

作　　者：郭亚云[1] 冷秀梅[2] 魏睦新[1,2] 

机构地区：[1]南京医科大学第一附属医院,江苏南京210029 [2]南京医科大学中西医结合研究所,江苏南京210029

出　　处：《现代中西医结合杂志》2013年第33期3663-3665,共3页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：江苏省中医局项目(2011(EE11))

摘　　要：目的探讨化痰消瘀方对慢性萎缩性胃炎(CAG)癌前病变的临床效果。方法选取268例CAG伴肠上皮化生或中、重度异型增生患者,均予口服化痰消瘀方,1剂/d,分2次服用,疗程为180 d,治疗前后均行电子胃镜检查和病理组织学检测。结果总有效率为94.78%;其中萎缩改善率为75.57%,肠上皮化生改善率为56.98%,不典型增生改善率为59.20%;胃痛改善率为87.31%,嗳气改善率为87.19%,食欲减退改善率为87.39%,各项临床病理症状积分治疗前后比较均有显著性差异。结论化痰消瘀方对慢性萎缩性胃炎癌前病变具有较好的临床疗效。Objective It is to approach the clinical effect of ＂Xiaoyu Huatan Chinese Medicine＂ （XHTM） on chronic atrophic gastritis of precancerous lesions. Methods 268 patients with intestinal metaplasia or mezzo and severe atypical hyperplasia were collected, and treated with XHCM for oral, 1 dose a day, maintained for 180 days. The examination by gastroscope and histopathology were executed before and after treatment. Results The overall efficiency was 94.78% （ P 〈 0.05 ） ; the integral improvement rate of clinical pathology with atrophic was 75.57% , with intestinal metaplasia was 59.68% , with atypical hyperplasia was 59.20% ; the integral improvement rate of clinical symptom with gastralgia was 87.31% , with belching was 87.19% , with anorexia was 87.39%. There was significant difference in scores of chinical symptoms between before and after treatment. Conclusion XHTM has better clinical effect in treatment of chronic atrophic gastritis of precancerous lesions.

关 键 词：慢性萎缩性胃炎 肠上皮化生 异型增生 癌前病变 逆转性 

分 类 号：R735.2[医药卫生—肿瘤]