5-HTTLPR基因多态性与强迫症的相关性研究  

Association study of 5-HTTLPR polymorphism with obsessive-compulsive disorder

作　　者：乔娟[1] 朱相华 赵后锋[2] 耿德勤[3] 

机构地区：[1]徐州医学院附属东方人民医院,江苏徐州221004 [2]江苏省徐州市东方人民医院心研所 [3]徐州医学院附属医院

出　　处：《精神医学杂志》2013年第5期351-353,共3页Journal of Psychiatry

基　　金：江苏省徐州市卫生局科技计划资助项目(编号:XWJ2011068)

摘　　要：目的探讨5-HTTLPR基因多态性与强迫症发病的相关性。方法将63例强迫症患者作为研究组,选取63名身心健康正常人为对照组,运用聚合酶链反应-限制性内切酶片段长度多态性分析技术(PCR-RFLP)检测5-HTTLPR基因多态性。入组时,采用自制的一般状况调查表了解两组人员的基本情况,对63例强迫症患者采用耶鲁-布朗强迫量表(YBOCS)评估强迫症状。结果研究组与对照组基因型频率和等位基因频率分布差异有统计学意义(χ2=33.149,P<0.05;χ2=18.473,P<0.05)。研究组LL基因型YBOCS评分[(32.26±6.25)分]明显高于LS型[(22.74±10.88)分]与SS型[(22.04±10.20)分](P<0.05)。Logistic回归分析显示:家族史、基因型、父母离异是强迫症发病的危险因素。结论 LL基因型可能是强迫症发病的重要危险因素之一,在强迫症患者中,LL基因型影响强迫症的严重程度。Objective To investigate the association between polymorphism of 5-HTTLPR and obsessive-compulsive disorder （OCD）.Methods The polymorphism of 5-HTTLPR was detected by using polymerase chain reactionrestriction fragment length polymorphism （PCR-RFLP） in 63 patients with OCD （OCD group） and 63 healthy controls （control group）.All cases in both groups were investigated with self-designed general information questionnaire,and patients in OCD group were evaluated with Yale-Brown obsessive-compulsive scale （YBOCS）.Results There were significant differences in distribution of genotype frequency （x2 =33.149,P 〈 0.05） and allelic frequency of 5-HTTLPR between OCD group and control group （x2 =18.473,P 〈 0.05）.Score of YBOCS was significantly higher in OCD patients with LL genotype （32.26 ± 6.25） than that in patients with LS （22.74 ± 10.88） or SS genotype （22.04 ±10.20） （P 〈0.05）.Logistic regression analysis found that risk factors of OCD included LL genotype,positive family history and parental divorce.Conclusion LL genotype of 5-HTTLPR maybe one of the risk factors of OCD.Moreover,LL genotype is associated with the severity of OCD.

关 键 词：强迫症 基因多态性 5-HTTLPR 

分 类 号：R749.7[医药卫生—神经病学与精神病学]