疼痛症状早期缓解与度洛西汀治疗抑郁障碍疗效的关系研究  

Relationship between early relieve of pain symptoms and the antidepressant efficiency of duloxetine

作　　者：王洪军[1] 王艳丽 王丽娜[1] 胡蕾[1] 

机构地区：[1]山东省精神卫生中心,济南250014 [2]武警山东省总队济南市支队卫生队

出　　处：《精神医学杂志》2013年第5期357-359,共3页Journal of Psychiatry

摘　　要：目的探讨疼痛症状早期缓解与度洛西汀的长期抗抑郁疗效之间的关系。方法使用汉密尔顿抑郁量表(HAMD)和疼痛的视觉模拟量表(VAS)分别在基线、治疗后2周末和12周末对44例患者的抑郁障碍及疼痛症状进行评估,使用治疗中需处理的不良反应症状量表(TESS)评定药物安全性。结果与基线比较,治疗2周末、12周末患者的HAMD评分、VAS评分均显著降低(P<0.05,P<0.01);治疗2周末疼痛症状的显著缓解是抑郁障碍患者12周末疗效的主要影响因素。结论对于伴有疼痛症状的抑郁障碍患者,早期疼痛症状缓解与否是度洛西汀治疗长期疗效的良好的预测因素。Objective To investigate the association of early relieve of pain symptoms with the long term antidepressant efficiency of duloxetine.Methods A total of 44 depressive patients with pain symptoms were treated with duloxetine for 12 weeks.All patients were assessed with Hamilton depression scale （HAMD）,pain symptoms visual analog scale （VAS） at baseline and at the end of the 2nd,12th week of the treatment.Treatment Emergent Symptom Scale （TESS） was used to evaluate the drug safety.Results Compared with the baseline,scores of HAMD and VAS decreased significantly at the end of the 2nd,12th week of the treatment （P 〈0.01,P 〈0.05 respectively）.A significant relieve of pain symptoms after 2 weeks of the duloxetine treatment was the main influencing factor for efficiency of 12-week duloxetine treatment.Conclusion The relieve of pain symptom in early stage of treatment can be used to predict outcomes of long-term treatment of duloxetine in depressive patients comorbided with pain symptoms.

关 键 词：抑郁障碍 疼痛症状 度洛西汀 

分 类 号：R749.4[医药卫生—神经病学与精神病学]