行为干预合并文拉法辛治疗抑郁症的疗效观察  

The efficacy of behavior intervention combined with venlafaxine for depression

作　　者：陈常云[1] 李守春[1] 李志春[1] 刘国英[1] 

机构地区：[1]山东省日照市精神卫生中心,276800

出　　处：《精神医学杂志》2013年第5期363-364,共2页Journal of Psychiatry

摘　　要：目的探讨抑郁症患者行为干预的有效性。方法将120例患者随机分为对照组和研究组,对照组给予文拉法辛治疗,研究组在文拉法辛治疗的同时进行针对性的行为干预,疗程均为8周,治疗前及治疗后第1、2、4、6、8周末采用汉密尔顿抑郁量表(HAMD)进行疗效评定。结果研究组治疗后第2周末起HAMD量表评分较治疗前显著下降(P<0.05,P<0.01),对照组治疗后第4周末起HAMD量表评分较治疗前显著下降(P<0.05,P<0.01)。治疗后第2、4、6周末,两组间比较有显著性差异(P<0.05),治疗后第8周末,两组间比较无显著性差异(P>0.05)。结论相对于单独使用抗抑郁药物,合并使用行为干预能快速、有效地缓解抑郁症状。Objective To explore the effect of behavior intervention on depression.Methods 120 patients with depression were randomized into intervention group （60 cases） treated with behavior intervention combined with venlafaxine for 8 weeks and control group （60 cases） treated with venlafaxine monotherapy for 8 weeks.All patients were assessed with Hamilton depression scale （HAMD） at baseline and since the end of the 1st,2nd,4th,6th,8th week of the treatment to evaluate the efficiency.Results Compared with the baseline,score of HAMD decreased significantly since the end of the 2nd week in intervention group （P 〈 0.05）,and since the end of the 4th week in control group （P 〈0.05）.At the end of the 2nd,4th and 6th week of treatment,there were significant differences in scores of HAMD between the two groups （P 〈 0.05）.But the significance disappeared at the end the 8th week （P 〉0.05）.Conclusion Behavior intervention combined with antidepressant have rapider and better efficiency for depressive disorder than antidepressant monotherapy.

关 键 词：行为干预 抑郁症 文拉法辛 

分 类 号：R749.4[医药卫生—神经病学与精神病学]