谷氨酰胺治疗急性胰腺炎肠屏障功能障碍临床观察  

Clinical observation on therapeutic effects of glutamine on intestinal barrier dysfunction in patients with acute pancreatitis

作　　者：寸志林[1] 刘剑[1] 邹利全[2] 王洪斌[2] 

机构地区：[1]解放军324医院急诊科,重庆400020 [2]解放军324医院消化科,重庆400020

出　　处：《西南国防医药》2013年第11期1181-1182,共2页Medical Journal of National Defending Forces in Southwest China

摘　　要：目的探讨谷氨酰胺在急性胰腺炎肠屏障功能障碍患者中的治疗作用。方法所有病例来自2011年3月-2012年9月在本院住院的患者62例，其诊断符合急性胰腺炎肠屏障功能障碍标准。随机分为对照组32例和治疗组30例，对照组采用常规治疗方法，治疗组在常规治疗方法的基础上，加用丙氨酰谷氨酰胺静脉注射治疗。分别记录两组腹部胀痛消失时间，检测治疗前后血液内毒素（LPS）浓度及尿乳果糖／甘露醇比值（L／M）。结果对照组腹部胀痛消失时间为（8．12±0．97）d，治疗组为（6．40±1．03）d，治疗组腹部胀痛消失时间明显短于对照组；治疗后治疗组LPS水平及IMM值较对照组低。结论在常规治疗急性胰腺炎肠屏障功能障碍患者时，加用丙氨酰谷氨酰胺可取得更好的疗效。Objective To discuss the therapeutic effects of glutamine on intestinal barrier dysfunction in patients with acute pancreatitis. Methods The subjects were 62 patients who were hospitalized between March 2011 and September 2012. Their diagnosis all met the criteria of acute pancreatitis complicated with intestinal barrier dysfunction. They were randomly divided into control group （32 cases） and treatment group （30 cases）. The control group received the traditional treatment. Based on the same treatment as the control group, the treatment group also received the intravenous injection with glutamine. The time of abdominal pain disappearing in both groups was recorded. The blood endotoxin concentration and the ratio of urine lactulose to mannitol （ L/M ） before and after the treatment were detected. Results The time of abdominal pain disappearing in the control group was （ 8.12 ±0.97 ） d, and that was （6.40 ±1.03 ）d in the treatment group. After the treatment, the blood endotoxin concentration and the ratio of L/M in the treatment group were lower than those in the control group. Conclusion Based on the traditional treatment of intestinal barrier dysfunction induced by acute pancreatitis, additional use of glutamine can achieve better curative effects.

关 键 词：急性胰腺炎 肠屏障 功能障碍 丙氨酰谷氨酰胺 

分 类 号：R576[医药卫生—消化系统]