GST-π和P-gp在大肠癌中的表达及意义  

EXPRESSION OF GST-Π AND P-GP IN COLORECTAL CANCER AND THEIR CLINICAL SIGNIFICANCES

作　　者：孔易[1] 郑纪宁[1] 

机构地区：[1]承德医学院,河北承德067000

出　　处：《承德医学院学报》2013年第6期453-455,共3页Journal of Chengde Medical University

摘　　要：目的:研究大肠癌谷胱甘肽-巯基-转移酶-π(GST-π)和P-糖蛋白(P-gp)的表达情况及二者与大肠癌临床病理特征的关系。方法:应用免疫组织化学S-P法检测86例大肠癌组织和52例远端正常组织(距癌灶>10cm)GST-π和P-gp的表达情况,并分析二者与大肠癌临床病理特征的关系。结果:大肠癌组织GST-π和P-gp的阳性表达率均明显高于远端正常组织(P<0.01,P<0.05)。大肠癌组织P-gp表达与淋巴结转移有关,有淋巴结转移者P-gp阳性表达率明显高于无淋巴转移者(P<0.05)。大肠癌GST-π和P-gp的表达呈正相关(P<0.01)。结论:GST-π、P-gp在大肠癌中的高表达可能与大肠癌原发性多药耐药有关,临床联合检测GST-π和P-gp可为制定合理的个体化化疗方案提供理论依据。Objective：To study the expression of glutathione-s-tmnsferase-n （GST-n） and P-glycoprotein （P-gp） in human colorectal cancer and their relationships with clinical pathological characteristics of colorectal cancer. Methods：S-P staining was used to detect the expression of GST-n and P-gp in 86 cases colorectal cancer and 52 cases distal nonnal tissue （〉 10crn from the cancer）. And the correlations between GST-π, P-gp expression and the clinical pathological characteristics of colorectal cancer were analyzed.Results：The positive expression rate of GST-π and P-gp in colorectal cancer were all significantly higher than that in distal normal tissues （P〈 0.01, P〈 0.05）. The expression of P-gp in colorectal cancer was related with lymph node metastasis： the positive expression rate of P-gp of patients with lymph node metastasis was significantly higher than that no lymph node metastasis （P〈 0.05）. There had positive correlation between GST-n and P-gp expression in colorectal cancer （P〈 0.01）. Conclusions： High expression of GST-π and P-gp in colorectal cancer may be associated with primary multidrug resistance of the cancer. Joint detection of GST-π and P-gp in clinic can provide theoretical basis for reasonable individual chemotherapy scheme.

关 键 词：大肠癌 谷胱甘肽-巯基-转移酶-π P-糖蛋白 免疫组织化学 

分 类 号：R735.3[医药卫生—肿瘤]