血HCY、ET-1、BNP及D-二聚体检测对急性脑梗死诊断的临床应用价值  

Clinical application value of blood HCY,ET-1,BNP and D-dimer detection in diagnosis of acute cerebral infarction

作　　者：周芸华[1] 徐勤燕[2] 潘秋荣[2] 

机构地区：[1]江苏大学附属常州武进人民医院检验科,江苏常州213002 [2]南京中医药大学附属常州中医院检验科,江苏常州213003

出　　处：《国际检验医学杂志》2013年第21期2846-2847,2849,共3页International Journal of Laboratory Medicine

摘　　要：目的探讨同型半胱氨酸(Hcy)、血浆内皮素-1(ET-1)、血清B型利钠肽(BNP)及D-二聚体对急性脑梗死诊断的临床价值。方法将50例急性脑梗死患者作为脑梗死组,50例健康者作为对照组,采集患者血液进行Hcy、ET-1、BNP和D-二聚体检测。结果脑梗死组患者和对照组健康者血Hcy、ET-1、BNP、D-二聚体检测结果比较,差异均有统计学意义(P<0.05)。Hcy、ET-1、BNP、D-D二聚体单项检测及4项联合检测脑梗死的阳性检出率分别为48.00%、36.00%、34.00%、46.00%及98.00%。结论血HCY、ET-1、BNP及D-二聚体检测在急性脑梗死患者的诊断、治疗及预防上具有较高的临床价值。Objective To explore the clinical value of homocysteine （Hcy）, plasma endothelin -1 （ET-1）, serum Btype natriuretic peptide （B-type natriuretic peptide,BNP） and D-dimer in the diagnosis of acute cerebral infarction. Methods 50 patients with acute cerebral infarction were served as cerebral infarction group and 50 healthy people as the control group. The blood samples were collected for Hcy, ET-1, BNP and D-dimer detection. Results Compared the detection results of blood Hcy, ET 1, BNP and Ddimer of patients in cerebral infarction group and people in control group, the differences all showed statistical significance（P〈 0.05）. The positive detection rates of single Hcy, ET 1, BNP, DI） dimmer detection and 4 combined detection were 48. 00%, 36.00%,34.00%,46. 00% and 98. 00%,respectively. Conclusion Detection of blood HCY,ET-1,BNP and D-dimer possesses high clinical value in diagnosis, treatment and prevention of patients with acute cerebral infarction.

关 键 词：急性脑梗死 利钠肽 脑 内皮素 半胱氨酸 D-二聚体 

分 类 号：R743.3[医药卫生—神经病学与精神病学]