CPP-ACP与不同浓度氟促进釉质再矿化的研究  

Remineralization of enamel promoted by casein phosphopeptide-amorphous calcium phosphate with different concentration of fluorin

作　　者：刘路[1] 杨林[1] 邹敏[1] 

机构地区：[1]西安交通大学口腔医院正畸科,陕西西安710004

出　　处：《上海口腔医学》2013年第5期533-536,共4页Shanghai Journal of Stomatology

摘　　要：目的:探讨酪蛋白磷酸多肽-无定形磷酸钙(casein phosphopeptide-amorphous calcium phosphate,CPP-ACP)与不同浓度氟离子联合应用对脱矿釉质再矿化的作用。方法:取正畸拔除的健康前磨牙30颗,乳酸凝胶法制备人工早期釉质脱矿后,随机分为对照组(5%CPP-ACP组)、实验组1(5%CPP-ACP+500 mg/L F-组)和实验组2(5%CPPACP+900 mg/L F-组),采用MH-5型显微硬度仪测量处理前、后釉质标本的显微硬度,采用SPSS 18.0软件包对数据进行统计学分析。结果:显微硬度测量显示,实验组2牙釉质的表面显微硬度变化显著高于实验组1(P<0.05)及对照组(P<0.01)。结论:CPP-ACP能够促进脱矿釉质再矿化,氟对其有加强协同作用。在一定范围内,氟浓度越高,协同作用越好。PURPOSE： To evaluate the effect of casein phosphopeptide-amorphous calcium phosphate （CPP-ACP） combined with different concentrations of fluoride on demineralization of enamel remineralization. METHODS： Extracted premolar teeth for orthodontic reason were immersed into lactic acid gel to prepare artificial white spot lesions. Then the specimens were randomly assigned to 3 groups： 5% CPP-ACP group as control, 5% CPP-ACP ＋500 mg/L F^- group and 5% CPP-ACP ＋900 mg/L F^- group, which were measured by micro-hardness tester. SPSS 18.0 software package was used for data analysis. RESULTS： There were significant differences in micro-hardness between control group and experimental group 1 and experimental group 2 by SNK-q test （P〈0.05）. CONCLUSIONS： CPP-ACP can make the demineralization of enamel remineralization occurs. F can promote the CPP-ACP remineralization. The increase of fluoride can make the CPP-ACP remineralization better below 1000-1500 mg/L.

关 键 词：酪蛋白磷酸多肽-无定形磷酸钙 氟 再矿化 显微硬度 

分 类 号：R783.5[医药卫生—口腔医学]