表皮生长因子对子宫肌瘤发生发展的影响  

Effects of EGF on the pathogensis and development of uterine leiomyoma

作　　者：甘晓卫 李卫平[2] 陈珠萍[2] 林其德[2] 丁传伟[2] 

机构地区：[1]上海市嘉定区南翔医院,201802 [2]上海第二医科大学附属仁济医院,200001

出　　处：《中国实用妇科与产科杂志》2000年第11期677-678,共2页Chinese Journal of Practical Gynecology and Obstetrics

摘　　要：目的　探讨表皮生长因子与子宫肌瘤的关系。方法　用酶联免疫吸附法 (ELISA)测定 2 2例子宫肌瘤患者子宫肌瘤组织和正常子宫平滑肌组织内表皮生长因子 (EGF)水平。结果　正常子宫平滑肌组织EGF质量浓度为 (16 6 4± 7 6 9)mg/L ,肌瘤组织EGF质量浓度为 (2 1 38± 7 75 )mg/L ,肌瘤组织EGF质量浓度显著高于正常平滑肌组织 (P <0 0 5 )。肌瘤组织EGF质量浓度分泌期为 (2 3 94± 5 83)mg/L ,增生期为 (17 2 3±7 13)mg/L ,两者之间有显著差异 (P <0 0 5 )。结论　EGF在子宫肌瘤的发生、发展中起重要作用 ,EGF的合成可能受孕激素的调节。Objective To study the relationship between epithelial growth factor(EGF) and uterine leiomyoma.Methods The level of EGF was measured by ELISA(Enzyme linked immunoabsorbence assay) in 22 cases of uterine leiomyoma and normal myometrium.Results The quality concentrations of EGF were(21 38±7 75)mg/L in leiomyoma,(16 64±7 69)mg/L in myometrium.There was a significant difference between these two tissues(P<0 05).In leiomyoma,the levels of EGF was (23 94±5 83)mg/L in secretory phase,which significantly increased than that in proliferative phase(17 23±7 13)mg/L(P<0 05).Conclusion Our findings suggest that EGF play an improtant role in leiomyomalic develpoment;EGF production in leiomyoma may be mainly controlled by progesterone.

关 键 词：表皮生长因子 子宫平滑肌瘤 ELISA EGF 

分 类 号：R737.330.2[医药卫生—肿瘤]