Expression of ectonucleotide pyrophosphatase-1 in end-plate chondrocytes with transforming growth factor beta 1 siRNA interference by cyclic mechanical tension  

作　　者：Xu Hong-guang Li Zi-rui Wang Hong Liu Ping Xiang Sheng-nan Wang Chuang-dong Zhang Xiao-ling 

机构地区：[1]Yijishan Hosp, Wannan Med Coll, Depathuent Orthoped Surg, Wuhu 241001, Anhui, Peoples R China [2]Chinese Acad Sci, SIBS, Inst Hlth Sci, Key Lab Stem Cell Biol, Shanghai 200025, Peoples R China [3]SJTUSM, Shanghai 200025, Peoples R China

出　　处：《Chinese Medical Journal》2013年第20期3886-3890,共5页中华医学杂志（英文版）

摘　　要：Background Ectonucleotide pyrophosphatase/phosphodiesterase （ENPP）-I is a membrane-bound protein that catalyzes the hydrolysis of extracellular nucleoside triphosphates to monophosphate and extracellular inorganic pyrophosphate （ePPi）. Mechanical stimulation regulates ENPP-1 expression. This study sought to investigate the changes in ENPP-1 expression after stimulation using cyclic mechanical tension （CMT）.Background Ectonucleotide pyrophosphatase/phosphodiesterase （ENPP）-I is a membrane-bound protein that catalyzes the hydrolysis of extracellular nucleoside triphosphates to monophosphate and extracellular inorganic pyrophosphate （ePPi）. Mechanical stimulation regulates ENPP-1 expression. This study sought to investigate the changes in ENPP-1 expression after stimulation using cyclic mechanical tension （CMT）.

关 键 词：cyclic mechanical tension  transforming growth factor beta 1 ectonucleotide pyrophosphatase/phosphodiesterase-1  extracellular signal-regulated kinase 1/2 

分 类 号：R363[医药卫生—病理学]