慢性酒精喂养加急性酒精灌胃的酒精性肝病小鼠模型(NIAAA模型或Gao-Binge模型)  

Mouse model of chronic plus binge ethanol feeding(NIAAA model or Gao-binge model)

作　　者：高斌[1] 常彬霞[1,2] 徐明江[1,3] 

机构地区：[1]美国国立卫生院酒精滥用与酒精中毒研究所肝病实验室,贝塞斯达20852 [2]解放军第三〇二医院非感染性肝病诊疗中心,北京100039 [3]北京大学医学部生理学与病生理学系,100191

出　　处：《传染病信息》2013年第5期307-311,共5页Infectious Disease Information

摘　　要：酒精性肝病是进展期肝病非常重要的原因之一,目前对其发病机制及治疗靶点的研究主要基于动物模型,因此建立一个与人类酒精性肝病类似的模型就至关重要。过去建立的一些酒精性肝病动物模型,或者肝损伤轻微,或者难于操作,近期由美国国立卫生院酒精滥用与酒精中毒研究所肝病研究室建立的新模型,即慢性酒精喂养加急性酒精灌胃的酒精性肝病小鼠模型(NIAAA模型或Gao-Binge模型),更接近于人类的饮酒方式,肝损伤更明显,而且容易操作,费用低和时间短。Alcoholic liver disease （ALD） is one of the most important reasons of chronic liver diseases. Currently, the studies on the pathogenesis and treatment targets of ALD are based on animal models, so it is important to establish an animal model similar to human ALD. The established animal models of ALD are either associated with mild liver injury or difficuhy in performing. Recent- ly, the Laboratory of Liver Diseases from the National Institute on Alcohol Abuse and Alcoholism （NIAAA）, National Institutes of Health, has established a simple chronic-binge ethanol feeding model （NIAAA model or Gao-Binge model）. This chronic-plus-binge ethanol feeding mimics the drinking pattern in many patients with alcoholic hepatitis and generates obvious liver injury. This model is easy to perform, and is time and cost efficient.

关 键 词：肝疾病 酒精性 小鼠 对照组 模型 动物 

分 类 号：R575[医药卫生—消化系统]